AI Article Synopsis
- Intramolecular spin-order transfer enhances signals for molecules that are generally hard to detect or found in low concentrations.
- The authors introduce an optimized pulse sequence that improves the transfer of spin-order between a paired set of nuclei and a nearby different nucleus, achieving maximum efficiency under ideal conditions.
- This technique aims to benefit hyperpolarization experiments with parahydrogen and research on the longevity of spin-order in hyperpolarized Magnetic Resonance Imaging applications.
Article Abstract
Intramolecular spin-order transfer is a useful technique for signal enhancement of insensitive and low-concentration molecular species. We present a closed-form, optimized pulse sequence which maximizes the efficiency of transfer between a singlet (para) nuclear pair and a vicinal heteronucleus. Neglecting the decay of coherences while the nuclei are in the transverse plane, the scheme is unity efficient for all combinations of internuclear scalar couplings. Efficiency loss due to T2-like decay is also minimized by keeping the sequence as short as possible. We expect this result to be useful for hyperpolarization experiments in which the spin-order originates in parahydrogen, as well as studies of singlet state decay aimed at longer-term storage of spin-order in hyperpolarized Magnetic Resonance Imaging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885468 | PMC |
| http://dx.doi.org/10.1016/j.jmr.2010.03.004 | DOI Listing |
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