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FYCO1 regulates autophagy and senescence via PAK1/p21 in cataract.
Arch Biochem Biophys
November 2024
Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China. Electronic address:
Article Synopsis
- The study investigates the role of FYCO1, an autophagy adaptor, in the development of age-related cataracts, which cause significant vision impairment.
- Using UVB irradiation to create cataract models in mice and cultured human lens cells, researchers observed structural damage and a decrease in FYCO1 expression associated with impaired autophagy.
- The findings suggest that FYCO1 influences cell senescence and cataract development through its interaction with p21 activated kinase 1 (PAK1), highlighting its potential role in combating cataract-related oxidative stress.
Ocular radiation exposure is negligible in normal volume endourological practice.
Ann R Coll Surg Engl
March 2024
Introduction: The annual dose limit for radiation exposure to the eye has been reduced recently; the eye is widely recognised as one of the most radiosensitive tissues in the body. There is minimal good quality research as to the radiation dose that the eye receives during endourological surgery and this study aimed to address this.
Methods: A prospective study was performed over an 8-month period at a single large teaching hospital in the UK.
Radiation cataract in Heterogeneous Stock mice after γ-ray or HZE ion exposure.
Life Sci Space Res (Amst)
February 2024
Center for Radiological Research, Columbia University, College of Physicians and Surgeons, 630W. 168th St., New York, NY,10032, , United States.
Health effects of space radiation are a serious concern for astronauts on long-duration missions. The lens of the eye is one of the most radiosensitive tissues in the body and, therefore, ocular health risks for astronauts is a significant concern. Studies in humans and animals indicate that ionizing radiation exposure to the eye produces characteristic lens changes, termed "radiation cataract," that can affect visual function.
View Article and Find Full Text PDFThe Radiobiological Characterization of Human and Porcine Lens Cells Suggests the Importance of the ATM Kinase in Radiation-Induced Cataractogenesis.
Cells
August 2023
INSERM U1296 Unit "Radiation: Defense, Health, Environment", 28 Rue Laennec, 69008 Lyon, France.
Studies about radiation-induced human cataractogenesis are generally limited by (1) the poor number of epithelial lens cell lines available (likely because of the difficulties of cell sampling and amplification) and (2) the lack of reliable biomarkers of the radiation-induced aging process. We have developed a mechanistic model of the individual response to radiation based on the nucleoshuttling of the ATM protein (RIANS). Recently, in the frame of the RIANS model, we have shown that, to respond to permanent endo- and exogenous stress, the ATM protein progressively agglutinates around the nucleus attracted by overexpressed perinuclear ATM-substrate protein.
View Article and Find Full Text PDFEvaluation of cataract formation in fish exposed to environmental radiation at Chernobyl and Fukushima.
Sci Total Environ
December 2023
School of the Environment, Geography and Geosciences, University of Portsmouth, Portsmouth PO1 3QL, United Kingdom. Electronic address:
Recent studies apparently finding deleterious effects of radiation exposure on cataract formation in birds and voles living near Chernobyl represent a major challenge to current radiation protection regulations. This study conducted an integrated assessment of radiation exposure on cataractogenesis using the most advanced technologies available to assess the cataract status of lenses extracted from fish caught at both Chernobyl in Ukraine and Fukushima in Japan. It was hypothesised that these novel data would reveal positive correlations between radiation dose and early indicators of cataract formation.
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