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Turner syndrome: fertility, familial clustering, and cancer risk.
Hum Reprod
December 2024
Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Study Question: Is there an increased risk of reproductive or colon cancer in women with Turner syndrome and their family members?
Summary Answer: Our data suggest that there is an increased risk for sigmoid colon cancer in women with Turner syndrome and an increased prostate cancer risk in second- and third-degree male relatives.
What Is Known Already: Turner syndrome has been associated with lower risk of breast cancer, but increased risk of gonadoblastoma and colon cancer in some, but not all studies. There is also evidence for a genetic predisposition to sex chromosome aneuploidy, which may indicate a predisposition to Turner syndrome and the associated cancer risk in family members.
fertilization (IVF) is a non-coital method of conception used to treat human infertility. Although IVF is viewed as largely safe, it is associated with adverse outcomes in the fetus, placenta, and adult offspring life. Because studies focusing on the effect of IVF on the male reproductive system are limited, we used a mouse model to assess the morphological and molecular effects of IVF on male offspring.
View Article and Find Full Text PDFAn Uncommon Cause of Testicular Infarct: A Case Report and Review of the Literature of Testicular Infarcts From Laparoscopic Inguinal Hernia Repair.
J Emerg Med
October 2024
Emergency Medicine Residency, Boonshoft School of Medicine, Wright State University, Fairborn, Ohio.
Background: Testicular ischemia requires timely diagnosis and definitive management to avoid serious consequences such as orchiectomy. It is almost always caused by testicular torsion; however, there are other causes to be aware of.
Case Report: A 32-year-old man developed testicular ischemia following a laparoscopic robotic-assisted inguinal hernia repair with preperitoneal mesh.
The effect of an educational animation on knowledge of testicular health and fertility of adolescents.
Hum Reprod
December 2023
School of Psychology, Cardiff University, Cardiff, UK.
Study Question: Does the provision of an educational animation, developed with young people, about testicular health and fertility impact the knowledge of these topics among adolescents?
Summary Answer: The development and provision of education on testicular health and fertility were welcomed by adolescents and associated with a significant increase in knowledge.
What Is Known Already: Young people may know less than they should about testicular health and male fertility topics. Lack of knowledge can have implications for health including late medical help-seeking for signs and symptoms of scrotal disorders, such as torsion, for which late presentation frequently results in testicular damage.
Factors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses.
Ann Intern Med
September 2023
Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Western Australia, Perth, Australia (B.B.Y.).
Background: Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements.
Purpose: To clarify factors associated with variations in sex hormone concentrations.
Data Sources: Systematic literature searches (to July 2019).
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