Background: Isolated sternal fractures (ISF) are uncommon injuries and after exclusion of other concomitant injuries, ISF can be classified as harmless injuries, and can be treated on outpatient basis.
Objective: Based on literature and own experience to make a simple algorithm in the diagnosis and treatment of ISF.
Patients And Methods: Retrospective analysis of medical records of patients who were admitted with ISF to the Clinic for Thoracic Surgery of UCC Sarajevo between January 2000 and January 2010.
Results: A review included 49 patients with ISF. The average age was 52.67 +/- 12.42 (range 21 to 81) years. Age group between 41 and 61 years was significantly more prone to ISF. Male/female ratio was 2.2:1 (34/15). The major cause of the injury, seen in 77.6% (38/49) cases, was an involvement in road traffic accidents (RTAs). Statistically, there is a significant difference (chi2 = 6.74; p = 0.009) in the frequency of occurrence ISF between drivers [55.1% (27/38)] and passengers [22.4% (11/39)]. Of the remaining eleven patients, four ISF were caused by falls at home, and seven by direct violence to the chest either in sport or in a fight. The sternal view radiography was diagnostic in all patients In most patients [83.7% (41/49)] the enzymatic values were elevated. ECGs were recorded in all cases, of which only 12.2% (6/49) had an abnormality. The average duration of hospitalization was 3.57 +/- 2.01 (range 1 to 7) days. It should be noted that 34.7% of patients were discharged in less than 24h and 73.5% were discharged in under 48h. Commonly used analgesic, metamizol, was applied in 98.0% (48/49) of cases. The combination of tramadol and metamizol was given in 63.3% (32/49) of patients.
Conclusion: Established results support the view that patients with ISF and no abnormality in ECG and cardiac enzymes during the early hours after injury are expected to have a benign course and can be discharged home within the first 24 to 48 hours. Proposed algorithm can be of assistance In making such decisions.
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Curr Pharm Des
January 2025
Director Operations and Medical Writing, RYT Lifesciences Pvt Ltd, Ahmedabad, Gujrat, India.
Objective: This study aimed to evaluate the effectiveness and safety of Altibrain® in combination with standard Autism Spectrum Disorder (ASD) treatment compared to standard ASD treatment alone in individuals diagnosed with ASD.
Method: A randomized, open-label trial was conducted involving 120 participants aged 3 to 17 years, randomly assigned to either the Standard ASD Treatment group or the Altibrain® + Standard ASD Treatment group. Sixty patients were randomly allocated to each Standard ASD Treatment group or the Altibrain® + Standard ASD Treatment group.
J Pers Med
January 2025
Unit of Pediatric Orthopedics and Traumatology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
: Femoral neck fractures are rare but serious injuries in children and adolescents, often resulting from high-energy trauma and prone to complications like avascular necrosis (AVN) and nonunion. Even rarer is the development of slipped capital femoral epiphysis (SCFE) following femoral neck fracture, which presents unique diagnostic and treatment challenges. SCFE can destabilize the femoral head, with severe cases requiring complex surgical interventions.
View Article and Find Full Text PDFCNS Neurol Disord Drug Targets
January 2025
Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab 142001, India.
Parkinson's disease (PD) is a progressive neurological condition characterized by both dopaminergic and non-dopaminergic brain cell loss. Patients with Parkinson's disease have tremors as a result of both motor and non-motor symptoms developing. Idiopathic Parkinson's disease (idiopathic PD) prevalence is increasing in people over 60.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Gastrin is secreted following a rise in gastric pH, leading to gastric acid secretion. Sleeve gastrectomy (SG), a bariatric surgery where 80% of the gastric corpus is excised, presents a challenge for gastric pH homeostasis. Using histology, and single-cell RNA sequencing of the gastric epithelium in 12 women, we observed that SG is associated with an increase in a sub-population of acid-secreting parietal cells that overexpress respiratory enzymes and an increase in histamine-secreting enterochromaffin-like cells (ECLs).
View Article and Find Full Text PDFLancet Diabetes Endocrinol
January 2025
Division of Diabetes & Nutritional Sciences, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK; Catholic University of the Sacred Heart, Rome, Italy; University Polyclinic Foundation Agostino Gemelli IRCCS, Rome, Italy.
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