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Evaluating iron deposition in gray matter nuclei of patients with acute ischemic stroke using quantitative susceptibility mapping.
Front Neurol
December 2024
Department of Radiology, Zigong First People's Hospital, Zigong, Sichuan, China.
Article Synopsis
- This study aimed to analyze brain iron changes in patients with acute ischemic stroke (AIS) using quantitative susceptibility mapping (QSM) to assist with early diagnosis and treatment.
- A total of 34 AIS patients and 30 healthy controls underwent QSM and conventional MRI, revealing significant increases in susceptibility values in specific brain regions (bilateral caudate nucleus and putamen) in AIS patients compared to controls.
- The study found that the highest diagnostic accuracy for distinguishing AIS from healthy individuals was 72.2%, while factors like smoking showed a notable correlation with increased susceptibility values, although overall clinical scores didn't significantly correlate with iron changes.
Early life stress shifts critical periods and causes precocious visual cortex development.
PLoS One
December 2024
Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
The developing nervous system displays remarkable plasticity in response to sensory stimulation during critical periods of development. Critical periods may also increase the brain's vulnerability to adverse experiences. Here we show that early-life stress (ELS) in mice shifts the timing of critical periods in the visual cortex.
View Article and Find Full Text PDFModulation of initial leftward bias in visual search by parietal tDCS.
PLoS One
December 2024
Psychological Science Research Institute, UCLouvain, Louvain-la-Neuve, Belgium.
Transcranial direct current stimulation (tDCS) has the potential to modulate spatial attention by enhancing the activity in one hemisphere relative to the other. This study aims to inform neurorehabilitation strategies for spatial attention disorders by investigating the impact of tDCS on the performance of healthy participants. Unlike prior research that focused on visual detection, we extended the investigation to visual search and visual imagery using computerized neuropsychological tests.
View Article and Find Full Text PDFD1 Receptor Functional Asymmetry at Striatonigral Neurons: A Neurochemical and Behavioral Study in Male Wistar Rats.
J Neurosci Res
January 2025
Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de Mexico, Mexico.
Lateralization of motor behavior, a common phenomenon in humans and several species, is modulated by the basal ganglia, a site pointed out for the interhemispheric differences related to lateralization. Our study aims to shed light on the potential role of the striatonigral D1 receptor in functional asymmetry in normal conditions through neurochemical and behavioral means. We found that D1 receptor activation and D1/D3 receptor coactivation in striatonigral neurons leads to more cAMP production by adenylyl cyclase in the striatum and GABA release in their terminals in the right hemisphere compared to the left.
View Article and Find Full Text PDFLanguage Dominance in Left-Handers: Unveiling Left Hemisphere Global Dominance With Specific Right Hemisphere Regional Dominance.
Cureus
November 2024
Department of Neurosurgery, Fukushima Medical University, Fukushima, JPN.
Article Synopsis
- The study examines how brain hemispheres relate to language processing in left-handed (LH) and right-handed (RH) individuals, finding that left-hemisphere dominance for language is common in both groups.
- Advanced imaging techniques, including fMRI, show subtle differences in language lateralization between LH and RH individuals, particularly during semantic processing tasks.
- Using high-resolution fMRI data from the Human Connectome Project, the research compares brain activity in LH and RH participants during language-related tasks, aiming to enhance understanding of language lateralization patterns.
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