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Reduction of PrP(C) in human cerebrospinal fluid after spinal cord injury. | LitMetric

Reduction of PrP(C) in human cerebrospinal fluid after spinal cord injury.

Prion

Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, AL, CA.

Published: December 2010

AI Article Synopsis

Article Abstract

It has been estimated that cerebrospinal fluid (CSF) contains approximately 80 proteins that significantly increase or decrease in response to various clinical conditions. Here we have evaluated the CSF protein PrP(C) (cellular prion protein) for possible increases or decreases following spinal cord injury. The physiological function of PrP(C) is not yet completely understood; however, recent findings suggest that PrP(C) may have neuroprotective properties. Our results show that CSF PrP(C) is decreased in spinal cord injured patients 12 h following injury and is absent at 7 days. Given that normal PrP(C) has been proposed to be neuroprotective we speculate that the decrease in CSF PrP(C) levels may influence neuronal cell survival following spinal cord injury.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933055PMC
http://dx.doi.org/10.4161/pri.4.2.11756DOI Listing

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