Summary: CGHnormaliter is a package for normalization of array comparative genomic hybridization (aCGH) data. It uses an iterative procedure that effectively eliminates the influence of imbalanced copy numbers. This leads to a more reliable assessment of copy number alterations (CNAs). CGHnormaliter is integrated in the Bioconductor environment allowing a smooth link to visualization tools and further data analysis.
Availability And Implementation: The CGHnormaliter package is implemented in R and under GPL 3.0 license available at Bioconductor: http://www.bioconductor.org
Contact: heringa@few.vu.nl
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http://dx.doi.org/10.1093/bioinformatics/btq155 | DOI Listing |
Nanomaterials (Basel)
February 2025
Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, School of Material Science and Engineering, Peking University, Beijing 100871, China.
The integration of two-dimensional (2D) nanomaterials into polymer-based packaging presents a promising avenue for sustainable, high-performance materials. This perspective explores the roles of colloidal interactions in the assembly of 2D materials into thin films for packaging applications. We begin by analyzing the types of colloidal forces present in 2D nanomaterials and their impact on dispersion and stability.
View Article and Find Full Text PDFSci Rep
March 2025
Graduate School of Natural Science and Technology, Okayama University, Okayama, 700-8530, Japan.
Pb-substituted La(O, F)BiS (Pb-LaOFBiS) exhibits improved superconducting properties and a resistivity anomaly around 100 K that is attributed to a structural transition. We have performed temperature(T)-dependent photoelectron holography (PEH) to study dopant incorporation sites and the local structure change across the anomaly. The PEH study of Pb-LaOFBiS provided evidence for the dominant incorporation sites of Pb and F: Pb atoms are incorporated into the Bi sites and F atoms are incorporated into the O site.
View Article and Find Full Text PDFMov Ecol
March 2025
Department of Ecology and Conservation Biology, Texas A&M University, 2258 TAMU, College Station, TX, 77843, USA.
Background: Freshwater megafishes are among some of the most commercially and ecologically important aquatic organisms yet are disproportionately threatened with range and population reduction. Anthropogenic alterations of rivers influencing migrations are among the most significant causes for these declines. However, migratory fishes do not always respond similarly to movement barriers and thus it is necessary to develop models to predict movements of freshwater migratory fishes in the face of anthropogenic alteration.
View Article and Find Full Text PDFBiochem Genet
March 2025
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Breast cancer is the most common invasive cancer diagnosed in females and is also the main cause of cancer-related deaths leading to more than 500,000 deaths annually. The present study aims to identify a promising panel of microRNAs (miRNAs) using bioinformatics analysis, and to clinically validate their utility for diagnosing breast cancer patients with high accuracy in a clinical setting. First, in the in silico phase of our study, using bioinformatics analysis and the data available in the GEO database, miRNAs that were increased in the interstitial fluid of the tumor tissues (differentially expressed miRNAs), were screened and their related target genes were selected.
View Article and Find Full Text PDFJ Chem Theory Comput
March 2025
Dipartimento di Chimica, Università di Torino, via Giuria 5, 10125 Torino, Italy.
We introduce a general approach for the simulation of quantum vibrational states of (symmetric and asymmetric) double-well potentials in molecules and materials for thermodynamic and spectroscopic applications. The method involves solving the nuclear Schrödinger equation associated with a one-mode potential of the type () = + + (with < 0 and > 0) and thus explicitly includes nuclear quantum effects. The potential, (), is obtained from density functional theory (DFT) calculations performed at displaced nuclear configurations along the selected normal mode, .
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