AI Article Synopsis
- Low-cost and flexible ion-sensitive field-effect transistors (ISFETs) have been developed for detecting pH levels and glucose from single-walled carbon nanotubes (SWCNTs) and a polymer layer.
- The pH sensors work by monitoring changes in the electronic conductance of the SWCNTs due to protonation and the voltage from an external reference.
- The glucose sensors utilize an enzyme (glucose oxidase) to detect glucose through local pH changes, showing a notable sensitivity and potential for biological applications.
Article Abstract
Low-cost, transparent, and flexible ion-sensitive field-effect transistors (ISFETs) are presented as pH and glucose sensors. Single-walled carbon nanotubes (SWCNTs) and poly(diallyldimethyammonium chloride, PDDA) are deposited by layer-by-layer (LbL) self-assembly between two metallic electrodes patterned on a polyethylene terephthalate substrate. The pH ISFETs are characterized based on the fact that the electronic conductance of SWCNTs nanocomposite is determined by molecular protonation/deprotonation of carboxylic groups on SWCNTs and by the external Ag/AgCl reference gate voltage. Glucose is detected by the local pH change in the vicinity of SWCNTs with the aid of glucose oxidase (GOx) enzyme. The glucose sensor shows a sensitivity of 18-45 microA/mM on a linear range of 2-10 mM. The apparent Michaelis-Menten constant is 14.2 mM, indicating a high affinity of LbL assembled GOx to glucose. The LbL self-assembly of nanomaterials and enzymes on the transparent and flexible substrate suggests various chemical and biological sensors suitable for in vivo application.
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| http://dx.doi.org/10.1016/j.bios.2010.03.003 | DOI Listing |
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