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Intraspinal and Intracranial Melanotic Perivascular Epithelioid Cell Tumor.
Radiology
December 2024
From the Department of Medical Imaging, University Hospitals Leuven, Leuven, Belgium (B.V.B., J.D.); and Department of Medical Imaging, Jessa Ziekenhuis, Stadsomvaart 11, 3500 Hasselt, Belgium (B.V.B.).
Melanotic neuroectodermal tumor of infancy arising in the skull: a case report.
Pan Afr Med J
April 2024
Department of Neurosurgery, Ibn Tofail Hospital, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy in Marrakech, Cadi Ayyad University, Marrakech, Morocco.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy is a rare, usually benign growth found in young children, primarily in the head and neck region.
- A case study highlights a 3-month-old girl with a growing mass on her forehead, which was found to be pressing on nearby structures during an MRI.
- After partial removal of the tumor confirmed the diagnosis, the patient experienced a recurrence, emphasizing the need for early diagnosis and surgical intervention to reduce risks of progression and reappearance.
A Case of Malignant Melanotic Schwannoma of the Trigeminal Nerve: A Case Report and Review of Literature.
Asian J Neurosurg
June 2023
Department of Neurosurgery, Bombay Hospital & Medical Research Centre, Mumbai, Maharashtra, India.
Intracranial melanotic schwannoma is quite rare, and involvement of the trigeminal nerve is even rarer. Early diagnosis and surgical excision are the mainstays of management. These tumors have a high tendency to recur and there is high possibility of metastasis.
View Article and Find Full Text PDFPreclinical Activity of 4-Demethyl-4-cholesteryloxycarbonylpenclomedine in Melanoma.
Anticancer Res
April 2023
Department of Chemistry, University of New Orleans, New Orleans, LA, U.S.A.
Background/aim: Temozolomide plays a role in treating melanoma refractory to immunomodulatory and mitogen-activated protein kinase-targeted approaches, but its efficacy is limited. 4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a polychlorinated pyridine cholesteryl carbonate. Its mechanism of action is considered to be via alkylation/adduct formation with N-guanine.
View Article and Find Full Text PDFTrigeminal Nerve Melanotic Schwannoma in Carney Complex.
Indian J Radiol Imaging
September 2022
Department of Neurosurgery, Apollo Hospitals, Sheshadripuram, Bengaluru, Karnataka, India.
Melanotic schwannoma (MS) is a rare peripheral nerve sheath tumor commonly found in the thoracic paraspinal region. It is present in an intracranial location rarely, with 18 out of 105 MS cases described in the literature. Trigeminal nerve was involved in only six of these cases.
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