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Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia-reperfusion injury.
Clin Transl Med
January 2025
Outcomes Research Consortium®, Houston, Texas, USA.
The gastrointestinal tract can be deranged by ailments including sepsis, trauma and haemorrhage. Ischaemic injury provokes a common constellation of microscopic and macroscopic changes that, together with the paradoxical exacerbation of cellular dysfunction and death following restoration of blood flow, are collectively known as ischaemia-reperfusion injury (IRI). Although much of the gastrointestinal tract is normally hypoxemic, intestinal IRI results when there is inadequate oxygen availability due to poor supply (pathological hypoxia) or abnormal tissue oxygen use and metabolism (dysoxia).
View Article and Find Full Text PDFHypoxia exposure blunts angiogenic signaling and upregulates the antioxidant system in endothelial cells derived from elephant seals.
BMC Biol
April 2024
Department of Integrative Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Background: Elephant seals exhibit extreme hypoxemic tolerance derived from repetitive hypoxia/reoxygenation episodes they experience during diving bouts. Real-time assessment of the molecular changes underlying protection against hypoxic injury in seals remains restricted by their at-sea inaccessibility. Hence, we developed a proliferative arterial endothelial cell culture model from elephant seals and used RNA-seq, functional assays, and confocal microscopy to assess the molecular response to prolonged hypoxia.
View Article and Find Full Text PDFCan Erythropoietin Reduce Hypoxemic Neurological Damages in Neonates With Congenital Heart Defects?
Front Pharmacol
November 2021
Department of Pediatrics, Children's Heart Institute, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
Article Synopsis
- - Congenital heart defects (CHD) are a common birth defect affecting about 1% of live births globally and can lead to significant neurological issues due to low oxygen delivery during critical brain development stages in neonates.
- - The review discusses prevention strategies for reducing brain damage from hypoxemia, highlighting the potential role of erythropoietin (EPO) as a treatment to protect the brain by being anti-apoptotic and antioxidant.
- - While maternal hyper-oxygenation has been studied for improving fetal oxygen, its clinical application is limited, leading researchers to investigate how EPO might help neonates with cyanotic CHD who face chronic low oxygen and related surgical injuries.
Development of Arterial Thrombosis in a Patient on Therapeutic Anticoagulation for COVID-19.
Cureus
September 2021
Pulmonary and Critical Care Medicine, Arrowhead Regional Medical Center, Colton, USA.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) virus has been known to manifest various non-pulmonary complications in the affected patient, including both venous and less frequently, arterial thrombosis. Ongoing research is necessary to determine who might benefit from therapeutic anticoagulation as well as potentially develop an algorithm to predict thromboembolic events in this patient population. We present a case of a 65-year-old man with a past medical history of hypertension, diabetes type 2, and a previous cerebrovascular accident who was admitted with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19).
View Article and Find Full Text PDFA case report of acquired methemoglobinemia rescued by veno-venous extracorporeal membrane oxygenation.
Medicine (Baltimore)
April 2021
Division of Cardiovascular Surgery, Department of Surgery, China Medical University Hospital, Taichung, Taiwan.
Rationale: Severe methemoglobinemia (Met-Hb) is rare. The delayed diagnosis and treatment often cause further damage. The management of cellular hypoxemia is challenging and the use of extra-corporeal membrane oxygenation (ECMO) has never been reported.
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