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Exploring brain perfusion in dogs with meningoencephalitis of unknown origin: A promising role for arterial spin labeling imaging.
J Vet Intern Med
December 2024
Unit of Diagnostic Imaging, Centre Hospitalier Vétérinaire ADVETIA, Vélizy-Villacoublay, France.
Background: Arterial spin labeling (ASL) is a noninvasive brain perfusion magnetic resonance imaging (MRI) technique that has not been assessed in dogs with meningoencephalitis of unknown origin (MUO).
Hypothesis/objectives: Assess brain perfusion changes characteristics before and after medical treatment, and investigate the role of ASL perfusion in the diagnosis and prognosis of MUO in dogs.
Animals: Thirty-one dogs with presumed MUO.
Dengue-Associated Acute Necrotizing Encephalopathy Is an Acute Necrotizing Encephalopathy Variant Rather than a Mimic: Evidence From a Systematic Review.
Pediatr Neurol
December 2024
Neurology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. Electronic address:
Background: Bilateral hemorrhagic thalamic lesions in dengue encephalitis resemble lesions seen in acute necrotizing encephalopathy (ANE). We investigate whether dengue-associated ANE (DANE) should be considered an ANE variant or a mimic.
Methods: Systematic review of dengue encephalitis literature from PubMed and SCOPUS (inception to December 31, 2022).
Impact of Epstein-Barr Virus Nuclear Antigen 1 on Neuroinflammation in PARK2 Knockout Mice.
Int J Mol Sci
October 2024
Department of Neurology, Juntendo University, Tokyo 1138431, Japan.
This study aimed to explore the intricate relationship between mitochondrial dysfunction, infection, and neuroinflammation, focusing specifically on the impact of pathogenic epitopes of the Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA1) in a mouse model of mitochondrial dysfunctions. The investigation included female middle-aged and C57BL/6J wild-type mice immunized with EBNA1 or with active experimental autoimmune encephalomyelitis (EAE) induction by the myelin oligodendrocyte glycoprotein (MOG) peptide. The mice developed more severe EAE than the wild-type mice.
View Article and Find Full Text PDFA pilot cross-sectional investigation of symptom clusters and associations with patient-reported outcomes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post COVID-19 Condition.
Qual Life Res
December 2024
National Centre for Neuroimmunology and Emerging Diseases, Griffith University, 1 Parklands Drive, Southport Gold Coast, Brisbane, QLD, 4222, Australia.
Article Synopsis
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post COVID-19 Condition (PCC) share similar debilitating symptoms, including fatigue and cognitive issues, impacting quality of life and functionality.
- The study involved Australian adults with ME/CFS and PCC, using self-reported questionnaires to assess symptoms and health outcomes, revealing significant differences in age and symptom associations between the two groups.
- Findings suggest that illness duration influences symptom severity, highlighting the need for clearer diagnostic criteria for PCC to better identify individuals at risk of developing chronic ME/CFS-like illnesses.
Retigabine, a potassium channel opener, restores thalamocortical neuron functionality in a murine model of autoimmune encephalomyelitis.
Brain Behav Immun
November 2024
Institute of Physiology I, University of Münster, Münster, Germany. Electronic address:
Background: Multiple Sclerosis (MS) is an autoimmune neurodegenerative disease, whose primary hallmark is the occurrence of inflammatory lesions in white and grey matter structures. Increasing evidence in MS patients and respective murine models reported an impaired ionic homeostasis driven by inflammatory-demyelination, thereby profoundly affecting signal propagation. However, the impact of a focal inflammatory lesion on single-cell and network functionality has hitherto not been fully elucidated.
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