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Sex differences in the association between family violence involvement and emergency mental health presentations: a longitudinal analysis.
Soc Psychiatry Psychiatr Epidemiol
December 2024
Centre for Forensic Behavioural Sciences, Swinburne University and Victorian Institute of Forensic Mental Health, Melbourne, Australia.
Purpose: Females experiencing family violence as victims are at increased risk of emergency department mental health presentations. However, few studies have examined this association for males and perpetrators. We examined whether family violence reports to police were associated with contemporaneous mental health presentations and whether this differed for males and females and those that the police identified as perpetrators and victims.
View Article and Find Full Text PDFIntegrative bioinformatic analysis to identify potential phytochemical candidates for glioblastoma.
Heliyon
December 2024
Department of Public Health, University of Health Sciences, Lahore, Pakistan.
Glioblastoma (GBM) is one of the most malignant forms of cancer with the lowest survival ratio. Our study aims to utilize an integrated bioinformatic analysis to identify hub genes against GBM and explore the active phytochemicals with drug-like properties in treating GBM. The study employed databases of DisGenet, GeneCards, and Gene Expression Omnibus to retrieve GBM-associated genes, revealing 142 overlapping genes.
View Article and Find Full Text PDFBackground: Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age groups of children younger than 5 years are scarce, and the burden in children older than 5 years and in adults is also understudied. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to assess the burden of, and trends in, diarrhoeal diseases overall and attributable to 13 pathogens, as well as the contributions of associated risk factors, in children and adults in 204 countries and territories from 1990 to 2021.
View Article and Find Full Text PDFPharmacological management of gambling disorder: A systematic review and network meta-analysis.
Compr Psychiatry
December 2024
Department of Psychiatry, Faculty of Medicine, University of Southampton, UK and Hampshire and Isle of Wight Healthcare NHS Foundation Trust, Southampton, UK.
Article Synopsis
- Clinical guidelines for medications treating gambling disorder are unclear, prompting a network meta-analysis to compare their efficacy and tolerability.
- The study reviewed 22 randomized controlled trials, ultimately analyzing 16 with nearly 1,000 participants, focusing on gambling symptom severity and quality of life as efficacy outcomes.
- Nalmefene showed the most promise in reducing gambling severity and improving quality of life, although it and naltrexone had higher dropout rates due to side effects, indicating lower tolerability compared to placebo.
The 2024 revision of the Declaration of Helsinki: a modern ethical framework for medical research.
Postgrad Med J
December 2024
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Panjiayuan, Nanli 17, Beijing 100021, China.
The Declaration of Helsinki, established in 1964, remains a foundational document in medical research ethics. This review examines the 2024 revision, endorsed by the 75th World Medical Association (WMA) Assembly, highlighting its impact on modern clinical research. Major updates include the shift from "subjects" to "participants," promoting autonomy and active involvement, and the introduction of dual ethical review requirements for cross-border studies to strengthen accountability.
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