Background: The site of Grotta d'Oriente, Island of Favignana, Sicily has yielded the complete skeleton of an adult female (OB) dated to the Mesolithic age. The cranial morphometry of this individual can provide us with some useful information about the peopling of Sicily in the Early Holocene period.
Aim: Morphological affinities of OB and other Sicilian Mesolithic specimens were assessed to verify hypotheses concerning the early peopling of Sicily.
Subjects And Methods: Craniofacial metric data were employed in a comparative analysis with European Upper Palaeolithic (UP), Mesolithic, Neolithic, and Copper/Bronze age samples, and contemporary Italians. Both a model-free and a model-bound approach were used not only to calculate craniometric distances, but also to assess the role played by gene flow and drift to produce the resulting pattern of variations and relationships.
Results: A Sicilian Mesolithic (SM) sample, including OB, resulted morphologically very close to an Italian Late UP comparative group. A general similarity among Western/Central European UP and Mesolithic groups was also detected.
Conclusion: Intense gene flow among hunter-gatherer populations accounts for close resemblances among various UP and Mesolithic groups. The beginning of a regional characterization is suggested by the morphological similarity between Italian Late UP and SM, and by decreasing gene flow among populations during the transition from the Upper Palaeolithic to the Mesolithic period.
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http://dx.doi.org/10.3109/03014461003712947 | DOI Listing |
J Transl Med
January 2025
Department of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China.
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J Transl Med
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School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, Guizhou, 550000, China.
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J Transl Med
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Department of Medical Oncology, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, 230031, Anhui, China.
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Department of Internal Medicine and Pediatrics, Hepatology Research Unit, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University, Ghent University Hospital, Ghent, Belgium. Electronic address:
Portal hypertension (PH) can cause severe complications in patients with advanced chronic liver disease (aCLD). The pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist lanifibranor reduces portal pressure in preclinical models of aCLD. Since the effect on PH might be secondary to fibrosis improvement, we investigated the effect of lanifibranor on PH, hepatic and splanchnic angiogenesis in mouse models of fibrotic and prehepatic non-fibrotic PH.
View Article and Find Full Text PDFVet Res Commun
January 2025
Faculty of Medical Technology, Prince of Songkla University, Songkhla, 90110, Thailand.
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