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| http://dx.doi.org/10.3201/eid1605.091920 | DOI Listing |
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Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans.
Nat Microbiol
January 2025
Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
T cells have been identified as correlates of protection in viral infections. However, the level of vaccine-induced T cells needed and the extent to which they alone can control acute viral infection in humans remain uncertain. Here we conducted a double-blind, randomized controlled trial involving vaccination and challenge in 33 adult human volunteers, using the live-attenuated yellow fever (YF17D) and chimeric Japanese encephalitis-YF17D (JE/YF17D) vaccines.
View Article and Find Full Text PDFDevelopment and optimization of an mRNA-vectored single-chain IgA1 isotype monoclonal antibody with potential to treat or prevent dengue virus infection.
Antiviral Res
January 2025
Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA; Institute for Global Health and Translational Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. Electronic address:
Dengue virus (DENV) is a rapidly expanding infectious disease threat that causes an estimated 100 million symptomatic infections every year. A barrier to preventing DENV infections with traditional vaccines or prophylactic monoclonal antibody (mAb) therapies is the phenomenon of Antibody-Dependent Enhancement (ADE), wherein sub-neutralizing levels of DENV-specific IgG antibodies can enhance infection and pathogenesis rather than providing protection from disease. Fortunately, IgG is not the only antibody isotype capable of binding and neutralizing DENV, as DENV-specific IgA1 isotype mAbs can bind and neutralize DENV while without exhibiting any ADE activity.
View Article and Find Full Text PDFDermatological manifestations during Dengue, Chikungunya, and Zika infections.
Curr Opin Infect Dis
November 2024
Dermatology Unit & Scientific Directorate, Galliera Hospital, Genoa, Italy.
Purpose Of Review: Arboviral infections caused by Dengue, Zika, and Chikungunya viruses continue to pose a significant global health threat, particularly in endemic regions. This review is timely because of the increasing prevalence of these infections, driven by factors such as urbanization and climate change. Dermatological manifestations of these viruses are crucial for early diagnosis, especially given the overlap in symptoms, which can complicate differential diagnosis.
View Article and Find Full Text PDFE2 Ubiquitin-Conjugating Enzymes Regulates Dengue Virus-2 Replication in .
Microorganisms
December 2024
Program in Public Health, School of Medicine, University of California, Irvine, CA 92617, USA.
, a major vector of dengue virus (DENV), has a global distribution. Identifying the key components of the ubiquitin system of essential for the replication of viruses could help identify targets for developing broad-spectrum antiviral strategies. This study explores the interaction between E2 ubiquitin-conjugating enzymes (Ubc9) and DENV-2 proteins (NS1, NS5, and E) using cell culture and mosquito models.
View Article and Find Full Text PDFDengue Virus Structural Proteins Are Expressed on the Surface of DENV-Infected Cells and Are a Target for Antibody-Dependent Cellular Phagocytosis.
Open Forum Infect Dis
January 2025
Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, New York, USA.
Article Synopsis
- Dengue virus (DENV) is a significant global health issue, with severe cases potentially worsened by antibodies that can enhance infection rather than neutralize it.
- Researchers are exploring the possibility of targeting DENV-infected cells for immune clearance to avoid antibody-dependent enhancement (ADE).
- This study found that DENV structural proteins are present on infected cell surfaces and can be recognized by immune antibodies, which may facilitate the clearance of infected cells without enriching viral material in certain immune cells.
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