In Singapore, after a major outbreak of dengue in 2005, another outbreak occurred in 2007. Laboratory-based surveillance detected a switch from dengue virus serotype 1 (DENV-1) to DENV-2. Phylogenetic analysis showed a clade replacement within DENV-2 cosmopolitan genotype, which accompanied the predominant serotype switch, and cocirculation of multiple genotypes of DENV-3.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953985PMC
http://dx.doi.org/10.3201/eid1605.091006DOI Listing

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