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Co-transcribed genes SA1833-SA1832 promote persister formation by regulating the transcription of holin-like gene lrgA in methicillin-resistant Staphylococcus aureus strain N315.
Int J Med Microbiol
December 2024
Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address:
Staphylococcus aureus, a facultative anaerobic gram-positive bacterial pathogen, has posed major threat to public health worldwide. Upon S. aureus infection, the host immune system is activated for clearance.
View Article and Find Full Text PDFSynergistic effect of ultrasound and antibiotics against Chlamydia trachomatis-infected human epithelial cells in vitro.
Ultrason Sonochem
January 2011
Department of Anatomy, Fukuoka University School of Medicine, Fukuoka, Japan.
To investigate whether or not the combined ultrasound and antibiotic treatment is effective against chlamydial infection, a new ultrasound exposure system was designed to treat chlamydia-infected cells. First, the minimum inhibitory concentrations of antibiotics against Chlamydia trachomatis were determined. Infected cultures were treated with antibiotics then sonicated at intensity of 0.
View Article and Find Full Text PDFThe effect of azithromycin on intracellular Legionella pneumophila in the Mono Mac 6 cell line at serum concentrations attainable in vivo.
J Antimicrob Chemother
September 2000
National Reference Centre of Hygiene and Institute of Environmental Medicine and Hospital Epidemiology, University Hospital Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany.
We investigated the antimicrobial efficacy of clinically meaningful, low concentrations of azithromycin against intracellular growth of two clinical isolates of Legionella pneumophila. The mature monocytic cell line Mono Mac 6 was used as a model to investigate the effects of antimicrobial agents on L. pneumophila.
View Article and Find Full Text PDFSimplified quantitative assay system for measuring activities of drugs against intracellular Legionella pneumophila.
J Clin Microbiol
May 1998
The First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
We developed a new simple assay for the quantitation of the activities of drugs against intracellular Legionella pneumophila. The cells of a murine macrophage-like cell line (J774.1 cells) allowed the intracellular growth and replication of the bacteria, which ultimately resulted in cell death.
View Article and Find Full Text PDFThe influence of human granulocytes and monocytes on the antibacterial activity of cefetamet against Staphylococcus aureus.
J Antimicrob Chemother
May 1995
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
The presence of human granulocytes and monocytes increased the activity of cefetamet against non-ingested Staphylococcus aureus. During ingestion of S. aureus by granulocytes, the activity of cefetamet was equal to that found in the absence of cells.
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