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Design and synthesis of novel SATE derivatives of acyclic isocytosine and 9-deazaadenine C-nucleosides. | LitMetric

Design and synthesis of novel SATE derivatives of acyclic isocytosine and 9-deazaadenine C-nucleosides.

Nucleosides Nucleotides Nucleic Acids

College of Pharmacy, Chosun University, Kwangju, Republic of Korea.

Published: March 2010

This article describes a very simple route for synthesizing novel lipophilic phosphate bis(t-bu-SATE) prodrugs of acyclic cyclobutylated C-nucleosides such as isocytosine 12 and 9-deazaadenine 19, which were prepared from 1,1-gem cyclobutyl dicarboxylate. Synthesized compounds were evaluated as potential antiviral agents against HIV virus. Some phosphate SATE prodrugs were more active against HIV than parent nucleosides.

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http://dx.doi.org/10.1080/15257771003745704DOI Listing

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