Palladium-catalyzed carboamination reactions between aryl bromides and 4-(but-3-enyl)-substituted oxazolidin-2-ones are described. These transformations afford bicyclic oxazolidin-2-one derivatives that can be converted to trans-2,5-disubstituted pyrrolidines in one step. The starting materials are easily prepared from amino acid precursors, and products that contain up to three stereocenters are generated with >20:1 dr.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873168 | PMC |
| http://dx.doi.org/10.1021/ol1006828 | DOI Listing |
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