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Pityriasis Rubra Pilaris and underlying malignancy.
QJM
October 2024
Department of Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China.
A 59-year-old man presented with a five-month history of widespread, salmon-colored, scaly plaques. Skin examination revealed salmon-colored plaques with "islands of sparing" on the trunk and waxy keratoderma on the palms and soles. Histopathology of the lesion showed alternating orthokeratosis and parakeratosis in vertical and horizontal directions, consistent with a diagnosis of pityriasis rubra pilaris (PRP).
View Article and Find Full Text PDFDistinguishing annular pustular psoriasis from subcorneal pustular dermatosis-A diagnostic dilemma in a 10-year-old boy.
Pediatr Dermatol
July 2023
Departments of Dermatology and Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Article Synopsis
- Subcorneal pustular dermatosis (SPD) and annular pustular psoriasis (APP) are rare skin conditions in children that are challenging to tell apart.
- A 10-year-old boy had a long history of red, scaly, ring-shaped patches with pustules, initially diagnosed as SPD, but his treatment and biopsy results pointed to APP.
- After starting treatment with adalimumab, the boy completely recovered, highlighting the similarities between SPD and APP and suggesting they might be variations of the same disease.
Concomitant nivolumab-associated Grover disease and bullous pemphigoid in a patient with metastatic renal cell carcinoma.
J Cutan Pathol
June 2023
Department of Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Article Synopsis
- A 73-year-old male with metastatic renal cell carcinoma developed both bullous pemphigoid (BP) and Grover disease (GD) while being treated with nivolumab, a type of immune checkpoint inhibitor (ICI).
- His skin condition included scaly papules and widespread lesions, with biopsies confirming both GD and BP through specific histopathological and immunofluorescence findings.
- The relationship between these ICI-induced conditions is complex, with T-cell activation potentially linking them, and the patient was effectively treated with dupilumab.
Hemorrhagic Bullous Lichen Sclerosus: A Case Report.
Am J Case Rep
October 2020
Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.
BACKGROUND Lichen sclerosus (LS) is a chronic autoimmune dermatosis characterized by white, sclerotic, atrophic plaques. Classic LS commonly occurs in the anogenital region, while extragenital lichen sclerosis typically occurs on the trunk and proximal extremities. Bullous lichen sclerosus is a rare variant that can occur in both genital and extragenital LS.
View Article and Find Full Text PDF[Mycosis fungoides bullosa: A rare clinical presentation].
Ann Dermatol Venereol
November 2020
CIC 1413, CRCINA, service de dermatologie, CHU de Nantes, université de Nantes, Nantes, France.
Introduction: Mycosis fungoides (MF) is the most common form of cutaneous lymphoma and usually manifests as erythematous and scaly patches or plaques. Its phenotypic or histologic presentation can be heterogeneous. Herein we report a very rare form of MF bullosa.
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