AI Article Synopsis
- The study focuses on the relationship between specific molecular markers and regional lymph node metastases (LNM) in papillary thyroid cancer (PTC).
- It involved 35 patients, with Group I showing no LNM and Group II having confirmed LNM, analyzing the expression of various markers.
- Significant differences were found in the expression of RET/PTC and EGFR between the groups, suggesting they may serve as predictive markers for LNM in PTC, potentially aiding in patient diagnosis and management.
Article Abstract
Introduction And Objective: Regional lymph node metastases (LNM) are a common finding in papillary thyroid cancer (PTC). Approximately half of patients have LNM at diagnosis. The aim of this study was to analyze immunohistochemically the combined expression of different PTC-related molecules in order to identify cases with a tendency to show LNM.
Patients And Methods: Thirty-five patients were included in the study. The patients were distributed in two groups. Group I included 19 patients with no histological evidence of LNM at diagnosis. Group II included 16 patients with histological evidence of cervical LNM. Samples were stained for RET/PTC, EGFR, p16(INk4a), p21(cip1), p27(kip1), BCL2, and pAKT.
Results: Expression of p21(cip1), p27(kip1), p16(INk4a), Bcl-2, and pAKT showed no differences between the two groups. However, RET/PTC and EGFR expression showed significant differences: in both cases, staining was more frequent in patients with LNM. Simultaneous positivity of RET/PTC and EGFR was a discriminative marker in patients with LNM. Finally, the combination of RET/PTC negative, EGFR negative and p16(INk4a) negative was found in none of the patients with LNM but in nearly half of those in group I.
Conclusions: Immunohistochemical analysis of several molecular markers could be useful in the phenotypic characterization of PTC. Application of these markers could enhance diagnosis and improve the management of patients with thyroid cancer.
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| http://dx.doi.org/10.1016/j.endonu.2010.02.005 | DOI Listing |
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