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Rapamycin inhibits re-endothelialization after percutaneous coronary intervention by impeding the proliferation and migration of endothelial cells and inducing apoptosis of endothelial progenitor cells. | LitMetric

AI Article Synopsis

  • Endothelial cell health is crucial for healing after damage to the arteries, particularly following procedures involving stent placement.
  • In studies with dogs and rats, rapamycin (sirolimus) was found to slow down the growth and movement of endothelial cells and their progenitors, which are important for repairing the endothelium.
  • The use of drug-eluting stents led to slower re-endothelialization compared to bare-metal stents, and rapamycin caused a reduction in critical growth factors and increased cell death among endothelial progenitor cells.

Article Abstract

Endothelial-cell function is important in the healing of damaged endothelium after percutaneous coronary artery damage. In 3 different animal models, we sought to determine whether rapamycin (sirolimus) affects the proliferation and migration of endothelial cells and endothelial progenitor cells. First, after we implanted stents in dogs, we found that re-endothelialization was impeded more by drug-eluting stents than by bare-metal stents, 30 days after percutaneous coronary intervention. Second, in vitro in rats, we found that 1-100 ng/mL of rapamycin time- and dose-dependently inhibited proliferation over 72 hr (with effects evident as early as 24 hr) and also dose-dependently induced endothelial progenitor-cell apoptosis. Finally, in vivo in rats, we observed that vascular endothelial growth factor expression was decreased after 5 days of rapamycin treatment. We conclude that rapamycin impedes re-endothelialization after drug-eluting stent implantation by inhibiting the proliferation and migration of coronary endothelial cells, inducing endothelial progenitor-cell apoptosis, and decreasing vascular endothelial growth factor expression in the circulation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851430PMC

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