AI Article Synopsis
- The study aimed to evaluate multiscale entropy (MSE) as a way to understand physiological complexity in Alzheimer's disease (AD) by analyzing resting state EEG activity.
- Researchers recorded EEG from 15 presenile AD patients and 18 healthy controls, finding that MSE results indicated less complexity at smaller scales and greater complexity at larger scales in the AD group, pointing to cognitive decline.
- These abnormal complexity profiles suggest that MSE could be a useful tool for better understanding the cortical dynamics associated with AD.
Article Abstract
Objective: Multiscale entropy (MSE) is a recently proposed entropy-based index of physiological complexity, evaluating signals at multiple temporal scales. To test this method as an aid to elucidating the pathophysiology of Alzheimer's disease (AD), we examined MSE in resting state EEG activity in comparison with traditional EEG analysis.
Methods: We recorded EEG in medication-free 15 presenile AD patients and 18 age- and sex-matched healthy control (HC) subjects. MSE was calculated for continuous 60-s epochs for each group, concurrently with power analysis.
Results: The MSE results from smaller and larger scales were associated with higher and lower frequencies of relative power, respectively. Group analysis demonstrated that the AD group had less complexity at smaller scales in more frontal areas, consistent with previous findings. In contrast, higher complexity at larger scales was observed across brain areas in AD group and this higher complexity was significantly correlated with cognitive decline.
Conclusions: MSE measures identified an abnormal complexity profile across different temporal scales and their relation to the severity of AD.
Significance: These findings indicate that entropy-based analytic methods with applied at temporal scales may serve as a complementary approach for characterizing and understanding abnormal cortical dynamics in AD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914820 | PMC |
| http://dx.doi.org/10.1016/j.clinph.2010.03.025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Changes in life satisfaction over six years in the general population: A longitudinal study with the Satisfaction With Life Scale (SWLS).
PLoS One
January 2025
Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.
Background: Satisfaction with life is a key concept for most individuals. The Satisfaction With Life Scale (SWLS) for measuring general life satisfaction has been widely analyzed in terms of cross-sectional associations. However, the knowledge about long-term changes in life satisfaction and the associations between such changes and changes in other variables of physical and mental health is limited.
View Article and Find Full Text PDFSprouting sideways: queer temporalities and kinship in donor conception.
Cult Health Sex
January 2025
Centre for Gender Research, University of Uppsala, Sweden.
Temporal constructs are central to reproduction and kinship, as epitomised by the pervasive concept of the biological clock within public imaginaries. While queer scholarship has problematised linear models of kinship and reproductive temporality, the specific temporalities associated with donor-conceived families have received less scholarly attention, despite the increasing prevalence of these family structures. In this article, we explore the question: how does donor conception reconfigure temporal logics.
View Article and Find Full Text PDFAltered brain functional connectivity in patients with tension-type headache.
Headache
January 2025
School of Psychology, Zhejiang Normal University, Jinhua, China.
Objective: To evaluate whether patients with tension-type headache (TTH) exhibit abnormal brain functional connectivity compared to healthy controls.
Background: TTH is one of the most prevalent headache disorders throughout the world. The present study delves into brain functional connectivity in patients with TTH to enhance the understanding of its underlying pathophysiology.
Three-year course of clinical high-risk symptoms for psychosis in the community: a latent class analysis.
Epidemiol Psychiatr Sci
January 2025
University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Aims: Clinical high-risk for psychosis (CHR-P) states exhibit diverse clinical presentations, prompting a shift towards broader outcome assessments beyond psychosis manifestation. To elucidate more uniform clinical profiles and their trajectories, we investigated CHR-P profiles in a community sample.
Methods: Participants ( = 829; baseline age: 16-40 years) comprised individuals from a Swiss community sample who were followed up over roughly 3 years.
Molecular-Scale Simulation of Wetting of Actin Filaments by Protein Droplets.
J Phys Chem B
January 2025
Department of Computer and Information Sciences, Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.
Liquid phase-separating proteins can form condensates that play an important role in spatial and temporal organization of biological cells. The understanding of the mechanisms that lead to the formation of protein condensates and their interactions with other biomolecules may lead to processing routes for soft materials with tailored geometry and function. Fused in sarcoma (FUS) is an example of a nuclear protein that forms stable complexes, and recent studies have highlighted its ability to wet actin filaments and bundle them into networks.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!