AI Article Synopsis
- Bronchial stump dehiscence is a serious complication after lung surgery, with high mortality rates, making effective healing methods critical.
- The study involved 36 rats undergoing left pneumonectomy, with half receiving bone marrow-derived stem cells to assess their impact on healing at the bronchial stump after surgery.
- Results indicated that rats treated with stem cells experienced fewer adhesions, reduced inflammation, and significantly improved tissue regeneration compared to the control group.
Article Abstract
Objective: Bronchial stump dehiscence is still the most feared complication for the thoracic surgeon, with mortality rates ranging from 25% to 75%. This study reports the histologic effect of adult stem cells in the healing process of the bronchial stump after lung resection.
Methods: A left pneumonectomy was performed in 36 Wistar rats. Half of them received previously labeled bone marrow-derived stem cells applied to the bronchial stump. In each group, 7 rats were sacrificed on day 7 and 11 rats were sacrificed on day 21. Macroscopic variables and histopathologic features were analyzed.
Results: On days 7 and 21, there were fewer adhesions in the stem cell group (P = .042 and .031, respectively). Bronchial stump restitutio ad integrum on day 21 was found predominantly in rats from the stem cell group (P = .012). At that time, the same group showed significantly less inflammation in every layer of the stump (P < .050).
Conclusions: Bone marrow-derived stem cells administered topically on a bronchial stump are able to migrate, reach the bronchial wall, and participate in the healing process. This induces fewer adhesions, less inflammatory response, and better regeneration of the tissue.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jtcvs.2010.03.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Utility of preoperative 18F-flurodeoxyglucose PET/CT scanning in preoperative evaluation and surgical planning for pulmonary tuberculosis.
Nucl Med Commun
February 2025
Department of Thoracic Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Objective: The objective of this study was to investigate the utility of preoperative 18F-FDG PET/CT scanning in preoperative evaluation and surgical planning for pulmonary tuberculosis.
Methods: The study involved a retrospective analysis of clinical data and preoperative chest 18F-FDG PET/CT data of 24 patients with pulmonary tuberculosis who underwent pneumonectomy at the Shanghai Public Health Clinical Center between December 2017 and January 2022.
Results: All 24 patients successfully underwent chest 18F-FDG PET/CT imaging, and complete data pertaining to the maximum standardized uptake value, mean standardized uptake value, minimum standardized uptake value, total lesion glycolysis, and metabolic tumor volume were obtained.
[Metastatic Lung Tumor with Bronchial Cast Shadow in Which Intraoperative Bronchoscopy Was Useful During Robotic Surgery].
Kyobu Geka
December 2024
Department of Thoracic Surgery, Tokyo Women's Medical University, Tokyo, Japan.
A man in his 60s, who had undergone surgery for rectal cancer, liver metastases, and lung metastasis, had a past history of myocardial infarction and ventricular fibrillation with reduced cardiac functions. He was referred to our department because of a pulmonary nodule shadow in the S2 right upper lobe and a bronchial cast shadow along the B2 bronchus. Robot-assisted thoracoscopic right S2 segmentectomy was performed and intraoperative bronchoscopy revealed a polyp-like tumor within B2a.
View Article and Find Full Text PDFMethods of bronchial stump buttressing in post-pneumonectomy bronchopleural fistula prevention: a systematic review.
Pol Przegl Chir
July 2024
Department of Thoracic Surgery, Poznan University of Medical Sciences, Poland.
Article Synopsis
- The bronchopleural fistula (BPF) is a serious complication that can occur after pneumonectomy, often addressed through various surgical buttressing techniques to improve healing.
- A review of literature on this topic included 27 articles, but only 16 were suitable for analysis due to factors like small sample sizes and irrelevant surgical procedures.
- The results indicated that three studies found significant benefits of using bronchial stump buttressing to reduce BPF risk, while the rest provided descriptive statistics or assessed blood perfusion in the tissue used.
Bronchopleural fistula (BPF), a common complication of lobectomy, is a pathological communication between the bronchus and the pleural space. The bronchial stump fistula (BSF), which is located on the bronchial stump, is a specific type of BPF. BSF can be directly diagnosed via bronchoscopy.
View Article and Find Full Text PDFTreatment of intractable bronchopleural fistula with a one-side-closed silicone stent using retrograde approach: A case report.
Respir Med Case Rep
October 2024
Department of Thoracic Surgery, Kochi Medical University, Kochi, Japan.
A male patient (age: 85 -years) with lung cancer underwent basal segmentectomy. Subsequently, he underwent emergency open window thoracotomy for a bronchial stump fistula. The general and nutritional conditions of the patient improved; nevertheless, natural closure of the fistula did not occur.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!