Objective: To evaluate the urine metabolic changes induced by sustained potassium citrate (KCit) treatment in patients with either hypocitraturia (HCit) or "unduly acidic urine pH" (UAUpH), and to determine the remission rate in those patients treated for more than 24 months.
Methods: We retrospectively reviewed the charts of 215 adult patients with recurrent renal stones whose only urinary metabolic risk factors were either HCit (n = 95) or UAUpH (n = 120) and had been treated with KCit for more than 3 months.
Results: In patients with Hcit (55 men and 40 women, mean age was 43 ± 14 years), Kcit therapy (average dose 48 ± 14.7 mEq/d) caused a sustained increase in urinary citrate to normal levels, in urinary potassium and pH and in serum potassium. In patients with UAUpH (73 men and 47 women; mean age 48.7 ± 12 years), Kcit therapy (average dose 42.8 ± 15.5 mEq/d) produced a significant increase in urinary pH, potassium, and uric acid. Remission rate was studied in 35 of these patients, whose median follow-up of 31.6 ± 14.3 months. All of these patients received a mean dose of potassium citrate of 45.4 ± 15.2 mEq/d. In 91% of these patients, there was no stone recurrence, similar for Hcit and UAUpH patients.
Conclusions: Treatment with potassium citrate corrects the metabolic abnormalities seen in patients with Hcit and UAUpH. This was associated with a very high remission rate of stone disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.urology.2010.02.029 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Effect of Osmotic Dehydration Conditions on the Potassium Content in Beetroot ( L.).
Molecules
November 2024
Department of Gastronomy Science and Functional Foods, Faculty of Food Science and Nutrition, Poznań University of Life Sciences, Wojska Polskiego 31, 60-624 Poznań, Poland.
Osmotic dehydration as a process of removing water from food by immersing the raw material in a hypertonic solution is used primarily to extend the shelf life of products and as a pretreatment before further processing steps, such as drying and freezing. However, due to the bi-directional mass transfer that occurs during osmotic dehydration, the process can also be used to shape sensory properties and enrich the plant matrix with nutrients. The purpose of this study was to evaluate the effect of osmotic dehydration on the absorption of potassium by beet pulp immersed in various hypertonic solutions (sucrose, inulin, erythritol, xylitol solutions) with the addition of three chemical forms of potassium (gluconate, citrate, chloride) using variable process conditions.
View Article and Find Full Text PDFHow does fertilizer management strategy in soilless blueberry cultivation change the phytochemical profile and phenoloxidases activity during fruit ripening?
J Sci Food Agric
December 2024
University of Belgrade, Institute for Multidisciplinary Research, Belgrade, Serbia.
Article Synopsis
- Highbush blueberries are popular for their taste and bioactive compounds, but how fertilizers affect their quality remains unclear.
- A study compared mineral-only fertilizers to a mix of organic and mineral fertilizers on the 'Bluecrop' blueberry cultivar, revealing that the mixed treatment improved organic acid and phenolic acid levels while increasing enzyme activities.
- The mixed fertilizer approach (Org-Min treatment) showed the best results for enhancing beneficial compounds, suggesting it's effective for cultivating blueberries without soil.
Refractory hypokalemia and metabolic acidosis induced by undifferentiated connective tissue disease secondary to immune checkpoint inhibitors: a case report and literature review.
Front Oncol
November 2024
State Key Laboratory of Oncology in South China, Guangzhou, China.
In the past, immune checkpoint inhibitors (ICIs) like camrelizumab have been associated with rheumatic immune-related adverse events (irAEs).To prevent serious adverse consequences, early diagnosis of rheumatic irAEs is crucial. A 40-year-old patient with malignant melanoma experienced severe hypokalemia and fatigue after 6 months of camrelizumab therapy, which was unresponsive to potassium chloride supplementation.
View Article and Find Full Text PDFThe safety and efficacy of regional citrate anticoagulation for multiple consecutive therapeutic plasma exchanges with fresh frozen plasma as a replacement solution.
Int Urol Nephrol
December 2024
The Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, Shaanxi, China.
Background: Therapeutic plasma exchange (TPE) is an important blood purification technology and most patients require multiple consecutive TPEs. Regional citrate anticoagulation (RCA) could be used for membrane therapeutic plasma exchange (mTPE). However, there is no research on the metabolic complications of the RCA for patients receiving multiple consecutive mTPEs with fresh frozen plasma (FFP) as a replacement solution.
View Article and Find Full Text PDFCase Report: Nephrocalcinosis in an infant due to vitamin-D food supplement overdose.
Front Pediatr
November 2024
Hospital Pharmacy, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella, Italy.
Article Synopsis
- Vitamin D is crucial for calcium regulation and overall health, with infants needing 400 IU daily, but the supplement market lacks consistent regulations that can lead to risks.
- A case study of a 22-month-old girl shows how an overdose—25 times the recommended dosage—led to nephrocalcinosis and various symptoms due to excessive vitamin D intake from an online supplement.
- This incident underscores the dangers of self-administering vitamin D without medical supervision, highlighting the need for cautious healthcare guidance on vitamin D supplementation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!