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Apolipoprotein E epsilon4 allele is associated with better performance language and visual memory in spinocerebellar ataxia type 3.
Eur J Neurol
January 2025
School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Background: The regulatory role of the apolipoprotein E (APOE) ε4 allele in the clinical manifestations of spinocerebellar ataxia type 3 (SCA3) remains unclear. This study aimed to evaluate the impact of the APOE ε4 allele on cognitive and motor functions in SCA3 patients.
Methods: This study included 281 unrelated SCA3 patients and 182 controls.
Phenomenological Mapping: A Method For Understanding Pre-Reflective Consciousness.
Integr Psychol Behav Sci
December 2024
Universidad del Desarrollo, Santiago de Chile, Chile.
Exploring the nuanced and often elusive realm of pre-reflective consciousness presents a methodological challenge, as it involves capturing experiences that arise prior to reflective thought and language. This article introduces Phenomenological Mapping, an innovative research method designed to systematically study the pre-reflective dimensions of human experience. Grounded in the foundational theories of Edmund Husserl (2012), Maurice Merleau-Ponty (2013), and Martin Heidegger (1992, 2008), the approach also integrates contemporary perspectives from Dan Zahavi (1999, Contemporary Phenomenology and Qualitative Research 5(1), 1-17, 2021), Shaun Gallagher (2006, 2017), and Evan Thompson (2010, 2017).
View Article and Find Full Text PDFCognitive abilities predict naturalistic speech length in older adults.
Sci Rep
December 2024
Healthy Longevity Center, University of Zurich, Zurich, Switzerland.
Past research has demonstrated the association between social engagement and the maintenance of cognitive abilities. However, inconsistent definitions of social engagement have posed challenges to systematically investigate this association. This paper addresses the role of social relationships in cognitive functioning among older adults, focusing on the real-life communication indicator-length of own speech-as a measure of social activity.
View Article and Find Full Text PDFAssociation of plasma BDNF and MMP-9 levels with mild cognitive impairment: a matched case-control study.
Sci Rep
December 2024
Department of Public Health, School of Medicine, Shihezi University, Shihezi, Xinjiang, China.
The prevalence of Alzheimer's disease (AD) is on the rise globally, and everyone who develops AD eventually experiences mild cognitive impairment (MCI) first. Timely intervention at an early stage of the disease may mitigate disease progression. Recent studies indicate that BDNF and MMP-9 play a significant role in the pathogenesis of AD.
View Article and Find Full Text PDFRapid Cognitive Deterioration in Progressive Supranuclear Palsy: A 1-Year Follow-Up Study.
Mov Disord Clin Pract
December 2024
Department of Neurology, National Clinical Research Center for Aging and Medicine, & National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Background: Nowadays, cognitive impairment has been characterized as one of the most vital clinical symptoms in progressive supranuclear palsy (PSP).
Objectives: Based on a relatively large cohort, we aimed to show the cognitive deterioration in different PSP subtypes during 1-year follow-up and investigate potential contributors for disease prognosis.
Methods: One hundred seventeen patients from Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI) cohort underwent neuropsychological tests and 1-year follow-up, with 73 diagnosed as PSP-Richardson syndrome (PSP-RS) and 44 as PSP-non-RS.
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