Objective: Monosymptomatic nocturnal enuresis is a common entity, with a prevalence of 10% at the age of 7 years. For its primary treatment, we compared the effect of combination medical therapy (imipramine with pseudoephedrine) with imipramine alone.
Materials And Methods: In this one-center prospective double-blind clinical trial, 100 school-age children (age range 5-12 years) were enrolled. They were divided into two groups, comparable in terms of age and other demographic factors: (A) adjusted doses of a combination of imipramine with pseudoephedrine, and (B) imipramine with placebo were administered. Improvement was defined as less than 2 wet nights per week.
Results: Four weeks after drug withdrawal, the response rate was 74% in group A in comparison to 52% in group B, this difference being statistically significant. There was a recurrence of enuresis in both groups during the 4 weeks after treatment was discontinued (10% increase in group A and 8% increase in group B).
Conclusion: The additive pharmacologic effects of imipramine with pseudoephedrine for the treatment of monosymptomatic nocturnal enuresis in children were well tolerated, and gave significantly faster results than single drug therapy using imipramine. The moderate-to-high recurrence rate following discontinuation of medical treatment indicates the need for a longer term study involving more cases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpurol.2010.03.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Treatment strategies for clozapine-induced nocturnal enuresis and urinary incontinence: a systematic review.
CNS Spectr
January 2022
Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Background: Clozapine is the most effective medication for treatment-refractory schizophrenia but is associated with significant adverse drug reactions, including nocturnal enuresis and urinary incontinence. This side effect can be burdensome and lead to medication nonadherence and psychotic relapse. Evidence to guide treatment of clozapine-induced nocturnal enuresis and urinary incontinence is sparse.
View Article and Find Full Text PDFClitoral Priapism in a Transgender Male.
Sex Med
December 2021
Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center School of Medicine, Amarillo, TX, USA. Electronic address:
Introduction: Clitoral priapism due to venous outflow obstruction is a rare event and medical emergency. Androgen-induced clitoromegaly in transgender men has not been previously identified as a risk factor.
Aims: Advance current knowledge on identification and treatment of clitoral priapism in the transgender male.
The drug treatment of delayed ejaculation.
Transl Androl Urol
August 2016
Department of Andrology & Sexology, Faculty of Medicine, Cairo University, Cairo 11562, Egypt.
Delayed ejaculation (DE) is an uncommon and a challenging disorder to treat. It is often quite concerning to patients and it can affect psychosocial well-being. Here we reviewed how DE is treated pharmacologically .
View Article and Find Full Text PDFMedication effects on periurethral sensation and urethral sphincter activity.
Female Pelvic Med Reconstr Surg
January 2016
From the *Division of Urogynecology and Pelvic Reconstructive Surgery, University of Alabama at Birmingham, Birmingham, AL; †Division of Urogynecology, Carilion Clinic, Roanoke, VA; ‡Division of Female Pelvic Medicine and Reconstructive Surgery, Northwestern University, Chicago, IL; §Department of Biostatistics and ∥Division of Gerontology, Geriatrics and Palliative Care, University of Alabama at Birmingham, Birmingham, AL.
Aim: The aim of this study was to characterize urethral neuromuscular function before and 2 weeks after medication therapy.
Methods: Premenopausal women without lower urinary tract symptoms were randomly allocated to 1 of the 6 medications for 2 weeks (pseudoephedrine ER of 120 mg, imipramine of 25 mg, cyclobenzaprine of 10 mg, tamsulosin of 0.4 mg, solifenacin of 5 mg, or placebo).
Comparison between imipramine and imipramine combined with pseudoephedrine in 5-12-year-old children with uncomplicated enuresis: a double-blind clinical trial.
J Pediatr Urol
February 2011
Department of Urology, Moradi Hospital, School of Medicine, Rafsanjan Medical Sciences University, Rafsanjan, Iran.
Objective: Monosymptomatic nocturnal enuresis is a common entity, with a prevalence of 10% at the age of 7 years. For its primary treatment, we compared the effect of combination medical therapy (imipramine with pseudoephedrine) with imipramine alone.
Materials And Methods: In this one-center prospective double-blind clinical trial, 100 school-age children (age range 5-12 years) were enrolled.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!