Cervical cancer is the first malignant disease of the women all over the world. Although the incidence of cervical cancer has been decreasing due to increased availability of screening tests, the diagnosis, management and prognosis of pregnancy associated with cervical cancer are still complex problems for clinical doctors. Here we report two cases of pregnancy associated with cervical cancer in our hospital and analyze the screening tests, the management, the neoadjuvant chemotherapy and the prognosis of the cases. Besides, we also review some literature and conclude by relating with our case reports that: cervical cytological test is significant for the prenatal examination and doing the test can obviously decrease the incidence of cervical cancer for pregnant women; In the clinical process, the doctors should take the social, ethical, medical condition etc. into account in the management for each trimester at presentation; The neoadjuvant chemotherapy has become a blessing for the pregnant women associated with cervical cancer and there is no bad result reported in the literature; The main factor influencing prognosis of pregnancy associated with cervical cancer is in the tumor stage.
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BMC Womens Health
January 2025
Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
Background: S. haematobium is a recognized carcinogen and is associated with squamous cell carcinoma of the bladder. Its association with high-risk(HR) human papillomavirus (HPV) persistence, cervical pre-cancer and cervical cancer incidence has not been fully explored.
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January 2025
Department of Obstetrics and Gynecology, University of California, Irvine, Irvine, CA, USA.
Cervical cancer is preventable with screening and vaccination approaches; however, access to these preventative measures is limited both nationally and globally and thus many women will still develop cervical cancer. Novel treatments and practice-changing research have improved cervical cancer outcomes over the past few decades. In this Review, we discuss clinical trials that have refined or redefined the treatment of cervical cancers across the early stage, locally advanced, persistent, recurrent and/or metastatic disease settings.
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January 2025
Department of General Surgery, Sanatorio Otamendi & Miroli (Otamendi & Miroli Hospital), University of Buenos Aires, Buenos Aires, Argentina.
Thyroid cancer is a common malignancy that requires comprehensive clinical evaluation prior to adequate surgical management. Over the last three decades thyroid surgery has tripled and is considered one of the most commonly performed procedures in general surgery. These procedures are associated with potential postoperative complications with significant deterioration in the patient's quality of life.
View Article and Find Full Text PDFCell Death Discov
January 2025
Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, China.
Cervical cancer (CC) is becoming a major health issue globally, and radiotherapy plays a crucial role in its treatment. However, the prognosis of some patients remains poor due to tumor resistance to the therapy. This study aimed to explore whether vitamin D could confer a more radiosensitive phenotype in CC based on our previous findings and detection using the database.
View Article and Find Full Text PDFInt Immunopharmacol
January 2025
Department of Gynecology, Dalian Women and Children's Medical Center (Group), Dalian Medical University, Dalian 116033, Liaoning, China. Electronic address:
Background: Cervical cancer is a prevalent form of cancer in women, and the inhibition of ferroptosis has been shown to promote the progression of cervical cancer tumours. This study aimed to investigate the role of PIN1 in regulating ferroptosis in cervical cancer, focusing on its ability to modulate the cGAS-STING pathway and the potential involvement of USP34 as an upstream regulator of PIN1.
Methods: PIN1-overexpressing and PIN1-knockdown cell lines were constructed.
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