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Atomic force microscopy combined with microfluidics for label-free sorting and automated nanomechanics of circulating tumor cells in liquid biopsy.
Nanoscale
January 2025
State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China.
Liquid biopsies are expected to advance cancer management, and particularly physical cues are gaining attention for indicating tumorigenesis and metastasis. Atomic force microscopy (AFM) has become a standard and important tool for detecting the mechanical properties of single living cells, but studies of developing AFM-based methods to efficiently measure the mechanical properties of circulating tumor cells (CTCs) in liquid biopsy for clinical utility are still scarce. Herein, we present a proof-of-concept study based on the complementary combination of AFM and microfluidics, which allows label-free sorting of individual CTCs and subsequent automated AFM measurements of the mechanical properties of CTCs.
View Article and Find Full Text PDFResearch Progress of Microneedles in Vaccine Delivery.
Curr Med Chem
January 2025
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, 250000, China.
Large-scale infectious diseases have become a significant threat to human health and safety. The successful invention of vaccines is the most powerful means for preventing infectious diseases and has greatly improved global human health. Even during the pandemic of COVID-19, which has affected the world, vaccines have played an irreplaceable role.
View Article and Find Full Text PDFA High-Precision Micro-Roll Forming Facility for Fuel Cell Metal Bipolar Plate Production.
Micromachines (Basel)
January 2025
School of Engineering, Deakin University, 75 Pigdons Rd., Waurn Ponds, Geelong, VIC 3216, Australia.
The metal bipolar plate is a critical component of the hydrogen fuel cell stack used in proton exchange membrane fuel cells. Bipolar plates must have high accuracy micro-channels with a high aspect ratio () between the channel depth and the half periodic width to achieve optimal cell performance. Conventional forming methods, such as micro-stamping, hydroforming, and rubber pad forming, cannot achieve these high ARs given that in these processes, material deformation is dominated by stretch deformation.
View Article and Find Full Text PDFEfficient Particle Manipulation Using Contraction-Expansion Microchannels Embedded with Hook-Shaped Arrays.
Micromachines (Basel)
January 2025
School of Mechanical and Electrical Engineering, China University of Mining and Technology, Xuzhou 221116, China.
Inertial microfluidics, as an efficient method for the manipulation of micro-/nanoparticles, has garnered significant attention due to its advantages of high throughput, structural simplicity, no need for external fields, and sheathless operation. Common structures include straight channels, contraction-expansion array (CEA) channels, spiral channels, and serpentine channels. In this study, we developed a CEA channel embedded with hook-shaped microstructures to modify the characteristics of vortices.
View Article and Find Full Text PDFEnhanced Fluid Mixing in Microchannels Using Levitated Magnetic Microrobots: A Numerical Study.
Micromachines (Basel)
December 2024
Mechatronics Engineering Department, Yildiz Technical University, Istanbul 34349, Turkey.
The efficient mixing of fluids at microscale dimensions presents challenges due to the dominant laminar flow regime which restricts convective mixing. This study introduces a numerical analysis of a novel microrobotic mixing system with a levitated propeller robot, driven by magnetic fields, within a Y-shaped microchannel with a square cross-section (500 × 500 μm). Our research investigates the fluid mixing effectiveness facilitated by the microrobot through various levitation heights and orientations to enhance the mixing index (MI).
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