The Keystone Symposium on the Molecular Basis for Biological Membrane Organization and Dynamics held in January this year offered new insights into the molecular machines at work in cells. Topics included the machinery responsible for the dynamic shape of organelles, the budding and fusion of vesicular carriers, and the intricate sorting systems that ensure the correct delivery of cellular components.
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| http://dx.doi.org/10.1038/embor.2010.60 | DOI Listing |
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Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks.
Nat Chem
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Institute of Bioengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Protein catalysis and allostery require the atomic-level orchestration and motion of residues and ligand, solvent and protein effector molecules. However, the ability to design protein activity through precise protein-solvent cooperative interactions has not yet been demonstrated. Here we report the design of 14 membrane receptors that catalyse G protein nucleotide exchange through diverse engineered allosteric pathways mediated by cooperative networks of intraprotein, protein-ligand and -solvent molecule interactions.
View Article and Find Full Text PDFDynamic tuning of terahertz atomic lattice vibration via cross-scale mode coupling to nanomechanical resonance in WSe membranes.
Microsyst Nanoeng
January 2025
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Nanoelectromechanical systems (NEMS) based on atomically-thin tungsten diselenide (WSe), benefiting from the excellent material properties and the mechanical degree of freedom, offer an ideal platform for studying and exploiting dynamic strain engineering and cross-scale vibration coupling in two-dimensional (2D) crystals. However, such opportunity has remained largely unexplored for WSe NEMS, impeding exploration of exquisite physical processes and realization of novel device functions. Here, we demonstrate dynamic coupling between atomic lattice vibration and nanomechanical resonances in few-layer WSe NEMS.
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View Article and Find Full Text PDFSplit tendon transfer of the posterior tibialis for spastic equinovarus foot deformity: Does tendon routing impact post-operative ankle kinematics?
Gait Posture
January 2025
Department of Orthopaedics, BC Children's Hospital, 4500 Oak St, Vancouver, BC V6H 3N1, Canada; The Motion Lab, Sunny Hill Health Centre, 4480 Oak St, Vancouver, BC V6H 3N1, Canada; University of British Columbia, Faculty of Medicine, Department of Orthopaedics, 317 - 2194 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Background: Split tendon transfer of the posterior tibialis (SPOTT) is a surgical procedure in which the split posterior tibialis tendon is transferred posterior to the fibula (PO) with insertion on the peroneus brevis tendon to rebalance the forces across the hindfoot. Routing of the split tendon through the interosseous membrane (IO) is a variation with the potential benefit of augmenting ankle dorsiflexion in swing.
Research Question: Does IO routing improve ankle dorsiflexion in swing and/or varus in stance compared to PO routing?
Methods: A retrospective chart review was completed to identify forty-two patients who underwent a SPOTT procedure for equinovarus foot deformity.
The WIRS motifs in Fat2 are required for Drosophila egg chamber rotation but not for elongation.
Development
January 2025
School of Science, Technische Universität Dresden, 01062 Dresden, Germany.
The elongation of tissues and organs is important for proper morphogenesis in animal development. In Drosophila ovaries, the elongation of egg chambers involves aligned Collagen IV fiber-like structures, a gradient of extracellular matrix stiffness and actin-based protrusion-driven collective cell migration, leading to the rotation of the egg chamber. Egg chamber elongation and rotation depend on the atypical cadherin Fat2.
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