Study Design: Biomechanical analysis of derotational load-to-failure of pedicle screw (PS) instrumentation in cadaveric thoracic spinal segments.
Objective: To investigate the derotational torque that can be applied to the thoracic spine through different linked constructs and evaluate the modes of failure.
Summary Of Background Data: Thoracic derotation with PSs has been shown to provide better 3 plane correction than other methods but the effects of linked PS constructs has not been studied.
Methods: Four groups of thoracic segments with different PS constructs were loaded to failure with a rotational torque applied to the construct to simulate the left to right derotational force applied to a typical idiopathic dextrorotary thoracic scoliosis curve. Single screw T4 segments instrumented on the medial (group 1M) and lateral (group 1L) sides, bilaterally-linked T5 segments (group 2), unilaterally-linked T6-T9 segments on the medial (group 3M) and lateral (group 3L) sides, and quadrangularly-linked T6-T9 segments (group 4) were loaded with MTS machine in a simulated thoracic derotation model.
Results: Single T4 PSs on the medial and lateral sides failed at 4.0 +/- 1.4 Nm (group 1M) and 6.1 +/- 2.5 Nm (group 1L), respectively. Bilaterally-linked T5 screws failed at 11.9 +/- 3.1 Nm (group 2). Unilaterally linked T6-T9 PS constructs on the medial and lateral sides failed at 21.2 +/- 7.5 Nm (group 3M) and 17.9 +/- 11.1 Nm (group 3L), respectively. Quadrangularly-linked PSs failed at 42.5 +/- 14.5 Nm (group 4). CONCLUSION.: A near linear increase in relative torque applied before failure was found with each additional PS linked. Linked constructs allow for significantly greater torque with less risk of PS breach of the spinal canal.
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http://dx.doi.org/10.1097/BRS.0b013e3181d85ec8 | DOI Listing |
EBioMedicine
January 2025
Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital; Columbus, OH, 43205, USA; Department of Pediatrics, College of Medicine, The Ohio State University; Columbus, OH 43210, USA. Electronic address:
Eur J Obstet Gynecol Reprod Biol
January 2025
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Los Angeles General Medical Center, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:
Objective: To assess clinical and obstetric characteristics associated with pregnant patients with a diagnosis of attention-deficit hyperactivity disorder (ADHD).
Methods: This serial cross-sectional study queried the Agency of Healthcare Research and Quality's Healthcare Cost and Utilization Project National Inpatient Sample. The study population was 16,759,786 hospital deliveries from 2016 to 2020.
Chemosphere
January 2025
Utrecht University, Utrecht, the Netherlands.
Carbohydr Res
January 2025
Glycochemistry Laboratory, School of Physical Sciences, Jawaharlal Nehru University, New Delhi, 110067, India. Electronic address:
Glycohybrids are biologically significant molecules with variety of biological functions and are found as structural motifs in numerous natural products. Here, we report the synthesis of various new coumarin-based O-glycoconjugates as glycohybrids that are chirally enriched and bridged by 1,2,3-triazoles ring system. The1,2,3-triazoles bridging was done via CuAAC click-chemistry.
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January 2025
Postgraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Sergipe, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. Electronic address:
Farnesol (FAR) belongs to terpenes group and is a sesquiterpene alcohol and a hydrophobic compound, which can be extracted from natural sources or obtained by organic chemical or biological synthesis. Recent advances in the field of nanotechnology allow the drawbacks of low drug solubility, which can improve the drug therapeutic index. Therefore, this study aimed to prepare the FAR inclusion complexes with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) through freeze-drying method, proposing their physicochemical characterization, comparing their toxicity, and evaluating their in vitro antibacterial activity.
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