Often existing cross-resistance to structure analogous antimalarials causes the need to find new active compounds against malaria parasites. For this purpose the traditional medicine of tropical countries has proved to be a treasury. A root extract of Cochlospermum angolense showed in vitro a remarkable activity against Plasmodium berghei in the DNA synthesis measurement with 3H-labelled hypoxanthine. This effect could be reproduced under in vivo conditions with the "4-day suppressive test" of rodent malaria.
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Bixa orellana (Bixaceae) seeds as a potential source of bioactive compounds for modulating postprandial hyperglycemia.
J Sci Food Agric
December 2024
Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida, Mexico.
Background: α-Amylase (α-AMY) and α-glucosidase (α-GLU) inhibitors are important for controlling postprandial hyperglycemia (PHG). Bixa orellana (annatto) reported inhibitory activity against these enzymes because of its bioactive compound content. However, an understanding of its inhibitory mechanisms and metabolic profile is necessary to establish its therapeutic potential.
View Article and Find Full Text PDFComprehensive profiling of traditional herbomineral formulation Manasamitra vatakam in rat brain following oral administration and in-silico screening of the identified compound for anti-Alzheimer's activity.
J Ethnopharmacol
February 2025
Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Health Science Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India. Electronic address:
Ethnopharmacological Relevance: Multi-targeted drug therapy has received substantial attention for the treatment of diseases of multifactorial origin, such as neurodegenerative diseases. Manasamitra vatakam (MMV) is a traditional Ayurvedic formulation used to improve cognitive impairment and mental illness. Here we have used a unique method for leveraging the barrier properties of the intestinal and blood-brain barrier (BBB) to screen and identify the bioactive molecules against Alzheimer's disease (AD).
View Article and Find Full Text PDFFirst Vesicular Self-Assembly of an Apocarotenoid Bixin in Aqueous Liquids and Its Antibacterial Activity.
Chem Asian J
December 2024
Department of Chemistry & Chemical Technology, Vidyasagar University, Midnapore, West Bengal, 721102, India.
Bixin 1 is the major constituent of the reddish carotenoids present in the seed-coat of Bixa orellana. The use of the extract of the seed-coat of Bixa orellana in food, cosmetics and garments is well known. The nano-sized long 24 C chain molecule has nine conjugated double bonds having extended conjugation with the '-COOH' and '-COOMe' groups present at the two ends of the molecule.
View Article and Find Full Text PDFEvaluation of the Hepatoprotective Properties of Traditional Formulations Based on Used in Benin.
Adv Pharmacol Pharm Sci
August 2024
Research Unit in Applied Microbiology and Pharmacology of Natural Substances Research Laboratory in Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi, Abomey-Calavi, Benin.
Article Synopsis
- Hepatic diseases pose a significant public health challenge, and traditional herbal treatments are commonly used in Benin for conditions like hepatitis, often without scientific evaluation.
- The study assessed the hepatoprotective properties and toxicity of 10 herbal recipes by testing different plant varieties and their proportions in treated Wistar rats.
- Findings indicated that the herbal recipes showed no acute toxicity and that their hepatoprotective effects increased with higher doses, with wild plant varieties performing better than cultivated ones, particularly when combined with certain other plants.
Evaluation of the potential of annatto seed powder to reduce the formation of heterocyclic amines in charcoal-grilled and pan-fried beef patties.
Food Chem
January 2025
Public Policies and Collective Health Department, Institute of Health and Society, Federal University of São Paulo, 136 Silva Jardim St., 11015-020, São Paulo, Brazil. Electronic address:
Various strategies are being explored to reduce the formation of undesirable compounds during the thermal processing of foods. This study investigates the impact of incorporating annatto seed powder (Bixa orellana L.) into beef patties to reduce the formation of heterocyclic amines (HAs) during charcoal-grilling and pan-frying.
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