Two new oleane-type triterpene saponins, lysimachiagenoside E (1) and lysimachiagenoside F (2), were isolated from the aerial parts of Lysimachia foenum-graecum Hance. The structures were elucidated on the basis of 1D and 2D NMR techniques, including (1)H-(1)H COSY, HMQC, HMBC, TOCSY, ROESY experiments as well as chemical methods.
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http://dx.doi.org/10.1080/10286020903523258 | DOI Listing |
Molecules
June 2023
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
Hance (Primulaceae) is a medicinal plant used for cold, pain, ascariasis, etc., in China. Triterpenoid saponins have been found to be the main components of this genus.
View Article and Find Full Text PDFEur J Pharmacol
August 2018
Department of Pharmacology, Gachon University School of Medicine, Incheon 21999, Republic of Korea; Gachon Medical Research Institute, Gil Medical Center, Incheon 21565, Republic of Korea. Electronic address:
Foenumoside B (FSB), a bioactive component isolated from the Lysimachia foenum-graecum extract (LFE), has been shown to possess anti-inflammatory effects, but the underlying molecular mechanisms involved have not been elucidated. Accordingly, the authors investigated the mechanisms responsible for the anti-inflammatory effects of FSB in murine macrophages activated by LPS. FSB suppressed the LPS-induced expressions of iNOS and COX-2 at protein and mRNA levels and consequently decreased NO and PGE2 production in RAW264.
View Article and Find Full Text PDFPhytochemistry
April 2017
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China. Electronic address:
Eleven oleanane-type triterpenoid saponins, foegraecumosides A-K, and eight known ones, were isolated from the aerial parts of Lysimachia foenum-graecum. Their structures were elucidated by spectroscopic data analyses and chemical methods. All isolated saponins were evaluated for their cytotoxicity against four human cancer cell lines (NCI-H460, MGC-803, HepG2, and T24).
View Article and Find Full Text PDFPLoS One
July 2017
Department of Pharmacology, Gachon University School of Medicine, Incheon, Republic of Korea.
Lysimachia foenum-graecum extract (LFE) and its active component foenumoside B (FSB) have been shown to inhibit adipocyte differentiation, but their mechanisms were poorly defined. Here, we investigated the molecular mechanisms responsible for their anti-adipogenic effects. Both LFE and FSB inhibited the differentiation of 3T3-L1 preadipocytes induced by peroxisome proliferator-activated receptor-γ (PPARγ) agonists, accompanied by reductions in the expressions of the lipogenic genes aP2, CD36, and FAS.
View Article and Find Full Text PDFPlant Pathol J
February 2016
Faculty of Department of Oriental Pharmaceutical Development, Laboratory of Plant Molecular Pathology, The Nambu University, Advanced Jungang-ro 23 street (Wolgye-dong 864-1), Gwangsan gu, Gwangju 506-706, Korea.
To identify a novel biopesticide controlling rice blast disease caused by Magnaporthe oryzae, 700 plant extracts were evaluated for their inhibitory effects on mycelial growth of M. oryzae. The L.
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