Structural modifications of phenolic monoterpenoid obtained by reacting carvacrol with various substituted alpha-chloro acetanilides, to improve biological activities which give the product with better yield and higher purity under mild reaction conditions with the help of microwave irradiation techniques.
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http://dx.doi.org/10.1080/10286020903455907 | DOI Listing |
Elife
March 2025
Department of Biology, Indian Institute of Science Education and Research, Pune, India.
Evolution of gene expression frequently drives antibiotic resistance in bacteria. We had previously (Patel and Matange, , 2021) shown that, in , mutations at the locus were beneficial under trimethoprim exposure and led to overexpression of dihydrofolate reductase (DHFR), encoded by the gene. Here, we show that DHFR levels are further enhanced by spontaneous duplication of a genomic segment encompassing and spanning hundreds of kilobases.
View Article and Find Full Text PDFPLoS One
March 2025
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Gardnerella vaginalis is the most frequently identified bacterium in approximately 95% of bacterial vaginosis (BV) cases. This species often exhibits resistance to multiple antibiotics, posing challenges for treatment. Therefore, there is an urgent need to develop and explore alternative therapeutic strategies for managing bacterial vaginosis.
View Article and Find Full Text PDFCrit Care Sci
March 2025
Division of Critical Care Medicine, Department of Pediatrics, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo - São Paulo (SP), Brazil.
Apnea is a major complication of acute respiratory tract infection in young infants and may lead to the need for ventilatory support. Caffeine is methylxanthine, which is considered the mainstay of pharmacologic treatment for apnea of prematurity. On the basis of neonatal guidelines, caffeine has been used as a respiratory stimulant for the treatment of acute respiratory tract infection-related apnea, despite low evidence of its ability to improve clinical outcomes.
View Article and Find Full Text PDFMicrobiology (Reading)
March 2025
School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Novel treatment options are needed for the gastric pathogen due to its increasing antibiotic resistance. The vitamin K analogue menadione has been extensively studied due to interest in its anti-bacterial and anti-cancer properties. Here, we investigated the effects of menadione on growth, viability, antibiotic resistance, motility and gene expression using clinical isolates.
View Article and Find Full Text PDFJ Epidemiol Glob Health
March 2025
Microbiological Type Culture Collection and Gene Bank (MTCC), CSIR Institute of Microbial Technology, Chandigarh, 160036, India.
Introduction: Antimicrobial resistance (AMR) is one of the major global concerns in the current scenario. Mass-gathering events in fast-developing and densely populated areas may contribute to antibiotic resistance. Despite meticulous planning and infrastructure development, the effect of mass gatherings on microbial ecosystems and antibiotic resistance must be investigated.
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