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BRD9 promotes the progression of gallbladder cancer via CST1 upregulation and interaction with FOXP1 through the PI3K/AKT pathway and represents a therapeutic target.
Gene Ther
November 2024
Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, China.
Article Synopsis
- Gallbladder cancer (GBC) is a highly aggressive cancer with a poor prognosis, often diagnosed at advanced stages, and current treatments are limited and ineffective.
- The study investigates the role of bromodomain-containing protein 9 (BRD9) in GBC, revealing that higher levels of BRD9 are linked to worse patient outcomes and decreased cell growth when suppressed.
- Targeting BRD9 with the inhibitor I-BRD9 shows potential in reducing GBC cell proliferation and may serve as a promising biomarker and therapeutic target.
Widespread myeloid sarcoma with KMT2A rearrangement involving the testis, oral cavity, heart, kidney and gallbladder without bone marrow involvement.
Leuk Res Rep
September 2022
100 Woods Road, Maplewood Hall, Apt 3-3, Valhalla, NY 10595, United States.
Myeloid sarcoma is a solid hematological tumor consisting of growing immature myeloid cells in tissues outside the bone marrow. Myeloid sarcoma presenting before the onset of bone marrow disease is rare. Here, we report the case of a young 35-year-old male who presented with testicular mass and was diagnosed with widespread myeloid sarcoma involving internal organs like heart, kidney and gallbladder.
View Article and Find Full Text PDFComparing Age at Cancer Diagnosis between Hispanics and Non-Hispanic Whites in the United States.
Cancer Epidemiol Biomarkers Prev
October 2021
Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, California.
Background: Population age structure may confound the comparison of age at cancer diagnosis across racial/ethnic groups. We compared age at cancer diagnosis for U.S.
View Article and Find Full Text PDFAn Unexpected Cause of Recurrent Jaundice after Resolution of Acute Hepatitis E.
Case Rep Gastroenterol
August 2020
Department of Gastro-Enterology, Universital hospital UZ Brussel, Jette, Belgium.
In this report, we describe a rare case of liver enzyme disturbance caused by myeloid sarcoma of the gallbladder and biliary tract. A 63-year-old man with progressive chronic myeloid leukemia presented with acute hepatitis. Viral serology revealed an infection with hepatitis E virus.
View Article and Find Full Text PDF[Pleural effusion as the first manifestation of pleural isolated myeloid sarcoma: a case report and literature review].
Zhonghua Jie He He Hu Xi Za Zhi
October 2020
Department of Respiratory, Dalian Municipal Central Hospital, Dalian 116033, China.
To analyze the clinic features of isolated myeloid sarcoma (IMS) involving the pleural cavity. A case of pleural isolated myeloid sarcoma (PIMS) with pleural effusion as the first manifestation was described. The related cases in literatures were reviewed with"myeloid sarcoma"and"pleural effusions"as the keywords to search China HowNet, Wanfang database and PubMed database.
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