Enantioenriched homoallylic ethers containing a alpha,beta-unsaturated ester (syn-vinylogous aldol products) were directly accessed by Lewis acid catalyzed crotylation utilizing chiral silane 2. The reagents were prepared by enantioselective Si-H insertion to an alpha-diazovinylacetates using Davies' Rh(2)(DOSP)(4) catalyst or chiral Cu(I) Schiff base complex.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164278 | PMC |
| http://dx.doi.org/10.1021/ol100604m | DOI Listing |
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