AI Article Synopsis
- - The study aimed to explore the link between certain variations of the HLA-DRB1 gene and severe chronic hepatitis B in patients.
- - Researchers analyzed genetic samples from 26 patients with severe chronic hepatitis B and compared them to 45 healthy individuals using specific testing methods.
- - Results showed a higher frequency of the HLA-DRB1 * 1301/1302 allele in patients with severe chronic hepatitis B, indicating its potential role in increasing susceptibility to the disease, unlike other alleles which showed no significant differences.
Article Abstract
Objective: To study the association between HLA-DRB1 gene polymorphism and severe chronic hepatitis B.
Methods: 26 patients with severe chronic hepatitis B were investigated for HLA-DRB1 gene polymorphism by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 45 normal healthy people by use of chi2-test of Microsoft SPSS 13.0.
Results: The frequency of HLA-DRB1 * 1301/1302 allele in severe chronic hepatitis B group was significantly higher than the frequency in the control group, while the frequencies of HLA-DRB1 * 1201/1202, 1501/1502 allele were not significantly different.
Conclusion: HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to severe chronic hepatitis B, While HLA-DRB1 * 1201/1202, 1501/1502 have no association with severe chronic hepatitis B.
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