A single social phenomenon (such as crime, unemployment, or birthrate) can be observed through temporal series corresponding to units at different levels (i.e., cities, regions, and countries). Units at a given local level may follow a collective trend imposed by external conditions, but also may display fluctuations of purely local origin. The local behavior is usually computed as the difference between the local data and a global average (e.g, a national average), a viewpoint that can be very misleading. We propose here a method for separating the local dynamics from the global trend in a collection of correlated time series. We take an independent component analysis approach in which we do not assume a small average local contribution in contrast with previously proposed methods. We first test our method on synthetic series generated by correlated random walkers. We then consider crime rate series (in the United States and France) and the evolution of obesity rate in the United States, which are two important examples of societal measures. For the crime rates in the United States, we observe large fluctuations in the transition period of mid-70s during which crime rates increased significantly, whereas since the 80s, the state crime rates are governed by external factors and the importance of local specificities being decreasing. In the case of obesity, our method shows that external factors dominate the evolution of obesity since 2000, and that different states can have different dynamical behavior even if their obesity prevalence is similar.
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http://dx.doi.org/10.1073/pnas.0910259107 | DOI Listing |
J Occup Med Toxicol
January 2025
School of Health Sciences, Department of Audiology, University of the Pacific, San Francisco, California, USA.
Background: Hazardous noise exposure is an important health concern in many workplaces and is one of the most common work-related injuries in the United States. Dental professionals are frequently exposed to high levels of occupational noise in their daily work environment. This noise is generated by various dental handpieces such as drills, suctions, and ultrasonic scalers.
View Article and Find Full Text PDFAlzheimers Res Ther
January 2025
Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA.
Background: PSEN1, PSEN2, and APP mutations cause Alzheimer's disease (AD) with an early age at onset (AAO) and progressive cognitive decline. PSEN1 mutations are more common and generally have an earlier AAO; however, certain PSEN1 mutations cause a later AAO, similar to those observed in PSEN2 and APP.
Methods: We examined whether common disease endotypes exist across these mutations with a later AAO (~ 55 years) using hiPSC-derived neurons from familial Alzheimer's disease (FAD) patients harboring mutations in PSEN1, PSEN2, and APP and mechanistically characterized by integrating RNA-seq and ATAC-seq.
Biol Sex Differ
January 2025
Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, 98195, USA.
Background: X chromosome inactivation (XCI) is a female-specific process in which one X chromosome is silenced to balance X-linked gene expression between the sexes. XCI is initiated in early development by upregulation of the lncRNA Xist on the future inactive X (Xi). A subset of X-linked genes escape silencing and thus have higher expression in females, suggesting female-specific functions.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, New York, USA.
Objectives: Pica is a non-nutritive eating behavior. The potential impact of pica on oral health and the association between pica and anemia are understudied. We examined the current evidence on the relationship between pica practices, anemia, and oral health outcomes.
View Article and Find Full Text PDFBMC Public Health
January 2025
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
Background: Understanding the risk factors of hypertension among women of reproductive age (18-44 years) is important for guiding health programs aimed at reducing the burden of hypertensive disorders in this population. Therefore, the objective of this study was to investigate predictors of self-reported hypertension among women of reproductive age in North Dakota.
Methods: Behavioral Risk Factor Surveillance System data for the years 2017, 2019, and 2021 were obtained from North Dakota Department of Health and Human Services.
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