The purpose of this study was to evaluate mechanisms underlying the action of selective serotonin reuptake inhibitors on the improvement of negative mood symptoms in premenstrual syndrome. We assessed relationships between serotonin (5-HT) levels in the brain (estimated from 5-HT concentrations in whole blood) and negative mood states during the premenstrual phase in 13 healthy women. Mood states were evaluated using the Profile of Mood States questionnaire. We also evaluated relationships between 5-HT and ovarian hormones (oestradiol and progesterone). A significant negative correlation was seen between 5-HT concentrations in whole blood and negative mood scores (tension-anxiety and fatigue) observed in the premenstrual phase. A significant positive correlation was observed between 5-HT and oestradiol in the premenstrual phase, but not in the follicular phase. These results suggest that healthy women with lower whole blood 5-HT concentrations in the premenstrual phase exhibit enhanced negative mood due to lower 5-HT concentrations at brain synapses, which may be caused in part by lower oestrogen concentration.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/01674821003770606 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association between adverse childhood experiences and menstruation-related symptoms among Japanese female workers: A cross-sectional study.
Child Abuse Negl
January 2025
Department of Mental Health, Graduate School of Medicine, The University of Tokyo, 7-3-1, hongi, Bunkyo-ku, Tokyo 113-0033, Japan.
Backgrounds: Menstruation-related symptoms are a common and serious health problem even without a specific diagnosis such as premenstrual dysphoric mood disorder (PMDD) or dysmenorrhea. Various adverse childhood experiences (ACEs) might be associated with menstruation-related symptoms, not only traditional traumatic events such as abuse, but also expanded ACEs such as childhood poverty, school bullying, or natural disasters.
Objective: This study examined the association between expanded ACEs (ACEs for Japanese) and menstruation-related symptoms among Japanese working women.
Patterns in affect and personality states across the menstrual cycle.
J Pers Soc Psychol
January 2025
Melbourne School of Psychological Sciences, University of Melbourne.
Affective, behavioral, and cognitive (i.e., personality) states fluctuate across situations and context, yet the biological mechanisms regulating them remain unclear.
View Article and Find Full Text PDFPsychological stress dysfunction in women with premenstrual syndrome.
Heliyon
November 2024
Mental Health Education Center, Xidian University, Xi'an, China.
Premenstrual syndrome (PMS) encompasses a range of emotional, physiological, and behavioral symptoms that occur during the luteal phase of the menstrual cycle (MC) and resolve with the onset of menstruation. These symptoms, which can include fatigue, physical pain, anxiety, irritability, and depression, significantly affect women's daily lives and overall well-being. In severe cases, PMS can progress to premenstrual dysphoric disorder (PMDD), profoundly impairing quality of life.
View Article and Find Full Text PDFPvuII-ESR1 gene polymorphism in premenstrual dysphoric disorder in South Indian women.
Indian J Psychiatry
October 2024
Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
Background: Premenstrual dysphoric disorder (PMDD) is a condition that affects nearly 3-9% of the women in the reproductive age during the luteal phase of each menstrual cycle characterized by symptoms varying in severity and affecting the quality of life. Earlier research studies conducted have reported independent relationships between PvuII-ESR1-polymorphism and psychological traits in PMDD and risk for cognitive, behavioral, and affective symptoms. However, as the studies are few in number and the results are not consistent, there is a need for our study to link between the PvuII-ESR1gene and PMDD.
View Article and Find Full Text PDFContraceptives and conditioning: Different profiles of fear and expectancy ratings during fear conditioning and extinction according to menstrual cycle phase and hormonal contraceptive use.
Biol Psychol
December 2024
Department of Experimental Psychology and Helmholtz Institute, Utrecht University, the Netherlands. Electronic address:
Hormonal contraceptives (HC) such as the oral contraceptive pill (OC) and the hormonal intrauterine device (IUD) have been associated with depressed mood, but research on their role in anxiety is scarce and inconsistent. In a fear acquisition and extinction paradigm, self-report fear, expectancy, and skin conductance responses (SCR) were assessed, along with sex hormone levels. Naturally cycling (NC) participants were measured during the mid-follicular and mid-luteal phases (within subjects, n = 26) and compared with OC (n = 36) and IUD (n = 25) users.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!