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Identification of natural product fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening. | LitMetric
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Identification of natural product fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening.

Ho-Man Lee Daniel Shiu-Hin Chan Fang Yang Ho-Yu Lam Siu-Cheong Yan Chi-Ming Che Dik-Lung Ma Chung-Hang Leung

Chem Commun (Camb)

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.

Published: July 2010

Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.

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 Source
http://dx.doi.org/10.1039/b926359dDOI Listing

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