Penile cancer is very rare in North America and Europe, as compared with the rest of the world. Squamous cell carcinoma (SCC) accounts for more than 95% of the cancer type. Paraneoplastic syndrome (PNS), a clinical syndrome of nonmetastatic systemic effects that occurs in patients with malignant disease, is often associated with SCC. However, the association of penile SCC with leukocytosis and hypercalcemia is very rare. We report a case of penile SCC involving a change in the patient's mental status along with hypercalcemia and leukocytosis; all three conditions resolved after the tumor was excised. We also discuss the possible factors contributing to hypercalcemia, leukocytosis and change in mental status in SCC. These three conditions and other features of PNS can significantly influence a patient's overall prognosis and, if recognized early, can play an important role in the care plan.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/SMJ.0b013e3181d7b802 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cutaneous Squamous Cell Carcinoma Producing Granulocyte Colony-stimulating Factor and Parathyroid Hormone-related Protein: A Case Report and Literature Review.
Intern Med
December 2024
Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
We herein report a case of cutaneous squamous cell carcinoma (SCC) characterized by paraneoplastic hypercalcemia-leukocytosis syndrome. The patient presented with systemic symptoms, including anorexia, a fever, and a tumoral lesion on the upper arm. Laboratory test results revealed hypercalcemia and leukocytosis.
View Article and Find Full Text PDFPneumococcal Endocarditis in a 49-Year-Old Male With Concomitant Myocarditis, Septic Spinal Arthritis, and Paraspinal Myositis: A Case Report.
Cureus
October 2024
Emergency Medicine, Mayo Clinic, Phoenix, USA.
Pneumococcal infective endocarditis (PIE) is a rare but serious infection often presenting with systemic complications such as septic emboli, myocarditis, and septic arthritis. This case report highlights a 49-year-old male who presented with acute-on-chronic lower back pain and fever, later diagnosed with PIE complicated by septic spinal arthritis, paraspinal myositis, and developing myocarditis. A 49-year-old male presented to the emergency department (ED) with worsening back pain and fever after treatment failure for suspected pyelonephritis.
View Article and Find Full Text PDFHypercalcemia-Associated Hodgkin's Lymphoma Presenting as Normal Pressure Hydrocephalus: A Case Report.
Cureus
October 2024
Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, USA.
Hodgkin's lymphoma is a malignancy of the lymphatic system that can rarely present with advanced-stage features such as spinal cord involvement and hypercalcemia. We present the case of a 63-year-old Caucasian male with advanced Hodgkin's lymphoma, presenting with hypercalcemia and symptoms resembling normal pressure hydrocephalus. The patient exhibited gait impairment, altered mental status, and urinary incontinence, forming the classic triad seen in normal pressure hydrocephalus.
View Article and Find Full Text PDFNecrotizing Fasciitis Mimicking Interstitial Cystitis: An Atypical Clinical Presentation.
Cureus
September 2024
Family Medicine, Ballad Health, Abingdon, USA.
Article Synopsis
- Necrotizing fasciitis is a dangerous, life-threatening infection that can be hard to diagnose due to its vague symptoms, making early detection and treatment critical to survival.
- A 60-year-old woman initially presented with urinary tract infection symptoms but quickly deteriorated, leading to a diagnosis of necrotizing fasciitis after severe abdominal pain and fever prompted further investigation.
- This case emphasizes the need for healthcare professionals to stay alert and consider serious underlying issues, even if symptoms seem minor, to prevent misdiagnosis and ensure prompt treatment.
Cancer and hidradenitis suppurativa.
Clin Dermatol
December 2024
DermSurgery Associates, Sugar Land, Texas, USA.
Article Synopsis
- * Factors like smoking, prolonged lesions, and certain treatments (like TNF-alpha inhibitors) may increase the risk of developing squamous cell carcinoma in these patients.
- * There is a need for careful monitoring of new or rapidly changing lesions in hidradenitis suppurativa patients, as they can mimic or hide underlying cancers, necessitating prompt medical evaluation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!