In this paper we evaluate the performance and usefulness of three semantic background knowledge sources for predicting synonymous anatomical terms across species boundaries. The reference sources under evaluation are UMLS, FMA-OBO and WordNet, which are applied to the anatomical ontologies of mouse and zebrafish. Our results show that the use of specialized knowledge sources leads to highly accurate predictions, verified through complete manual curation, which can be further improved by combining multiple of said sources. We argue that these three references complement each other in terms of granularity and specificity. From our results we conclude that these references can be used to create reliable ontology mappings with minimal human supervision.
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http://dx.doi.org/10.2390/biecoll-jib-2010-124 | DOI Listing |
Small
December 2024
Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Straße 24-25, 14476, Potsdam, Germany.
Antimicrobial resistance (AMR) is a major cause of death worldwide. This urges the search for alternatives to antibiotics, and antimicrobial polymers hold promise due to their reduced susceptibility to AMR. The topology of such macromolecules has a strong impact on their activity, with bottlebrush architectures outperforming their linear counterparts significantly.
View Article and Find Full Text PDFChem Biodivers
December 2024
Latvian Institute of Organic Synthesis, Natural Products, Riga, Latvia, LV-1006, Riga, LATVIA.
Kitasatospora continue to be a rich source of chemically diverse and bioactive peptide natural products. This review highlights two strategies in peptide natural products research of Kitasatospora, 1) natural product-first approach guided by a major compound, biological activity or genomic analysis, and 2) enzyme-first approach guided by bioinformatic tools to construct a sequence similarity network for the discovery of biosynthetic enzymes. The structures of peptides, biosynthetic origins of unique building blocks, recent reports of post-translational modifying enzymes for constructing these peptides, and knowledge gap in biosynthesis will also be presented.
View Article and Find Full Text PDFEcol Lett
January 2025
Asian School of the Environment, Nanyang Technological University, Singapore, Singapore.
Insects represent most of terrestrial animal biodiversity, and multiple reports suggest that their populations are declining globally due to anthropogenic impacts. Yet, a high proportion of insect species remain undescribed and limited data on their population dynamics hamper insect conservation efforts. This is particularly critical in tropical biodiversity hotspots such as Southeast Asia.
View Article and Find Full Text PDFObjective: To analyze the effect of implementing continuity of care for postoperative patients with cervical cancer, to improve the continuity of care model in China, and to provide comprehensive, continuous, and personalized care services for patients.
Methods: PubMed, Web of Science, Science Direct, China Knowledge Network, Wanfang database, China Biomedical sources Service System, Wipro, Cochrane Library, Embase, and other databases were searched for relevant sources on the effect of continuity of care on postoperative cervical cancer patients. The Cochrane Handbook of Systematic Evaluation and Revman 5.
Front Microbiol
December 2024
Department of Orthopedics, Wuxi Hospital of Traditional Chinese Medicine, Wuxi, Jiangsu, China.
Background: Emerging research indicates that gut microbiota (GM) are pivotal in the regulation of immune-mediated bone diseases. Nonunion, a bone metabolic disorder, has an unclear causal relationship with GM and immune cells. This study aims to elucidate the causal relationship between GM and nonunion using Mendelian Randomization (MR) and to explore the mediating role of immune cells.
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