Objectives: Efforts are underway to develop advanced alcohol detection technologies suitable for use in all vehicles to prevent driving with an illegal blood alcohol concentration (BAC). Attitudes toward having this technology in all vehicles were assessed.
Methods: A nationally representative sample of people 18 and older was interviewed by telephone.
Results: Eighty-four percent of survey respondents supported requiring alcohol ignition interlocks in the vehicles of convicted driving while intoxicated (DWI) offenders. Sixty-four percent said having advanced alcohol detection technology in all vehicles is a good or a very good idea, assuming the technology is reliable; 30 percent said it is a bad idea. Most people in favor said that it would prevent alcohol-impaired driving, save lives, or prevent crashes. Among respondents who said it is a bad/very bad idea, one third cited concerns about privacy or government interference; 20 percent said not all drivers need screening. Support was highest among respondents who do not drink, but it also was favored by the majority of respondents who drink, respondents who have driven within 2 hours of consuming alcohol, and respondents who may have driven when they were above the legal limit for alcohol. Forty-two percent of respondents who drive said they would want an advanced alcohol detection device in their next vehicles if it were available as an option at a reasonable price. Of the 54 percent who said they would not want a device, 44 percent said they do not drink alcohol so it would not be useful. Most people said a price less than $500 would be reasonable.
Conclusions: It appears that the majority of the U.S. population is receptive to the idea of having advanced alcohol detection devices in all vehicles to prevent people from driving with an illegal BAC, although less than half say they would purchase a device in their next vehicles.
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http://dx.doi.org/10.1080/15389580903515419 | DOI Listing |
BMC Gastroenterol
January 2025
Department of Nephrology, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
Background: Gallstone disease (GSD) is associated with obesity. The Cardiometabolic Index (CMI), a metric that accurately assesses central adiposity and visceral fat, has not been extensively studied in relation to GSD risk. This study investigates the link between CMI and GSD incidence in U.
View Article and Find Full Text PDFAAPS PharmSciTech
January 2025
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China.
Amorphous solid dispersion (ASD) is one of the most studied strategies for improving the dissolution performance of poorly water-soluble drugs, but ASDs often have low drug loadings, thereby necessitating larger dosage sizes. This study intended to create Soluplus® (SOL)-based microparticle ASDs with high drug loading (up to 60 w/w%) and long-term stability (at least 16 months) using electrospraying to enhance the dissolution of poorly water-soluble celecoxib (CEL). X-ray diffraction (XRD) and differential scanning calorimetry (DSC) analyses showed that the electrosprayed SOL-CEL microparticles were amorphous, and Fourier transform infrared spectroscopy (FTIR) data indicated the presence of hydrogen bonding between SOL and CEL in the microparticles, which helped stabilize the ASDs.
View Article and Find Full Text PDFBiomater Adv
January 2025
Department of Biomedical Sciences, National Chung Cheng University, Chia-Yi 62102, Taiwan, ROC.
Encapsulated BV6 and SM164, two bivalent second mitochondria-derived activator of caspase (Smac) mimetics, in etoposide (ETO)-lipopolymer nanoparticles (NPs) have been developed to deplete inhibitor of apoptosis proteins (IAP), impair DNA, and produce antagonistic effects on glioblastoma multiforme (GBM) in nude mice. The NPs, composed of cocoa butter (CB) and polyvinyl alcohol (PVA), were stabilized by glycerol monostearate and Pluronic F-127, and grafted with transferrin (Tf) and wheat germ agglutinin (WGA) to dock the blood-brain barrier (BBB) and degenerated dopaminergic neurons. The dual-targeting NPs increased the BBB permeability of BV6, SM164 and ETO via recognizing Tf receptor (TfR) and N-acetylglucosamine that are abundantly expressed on brain microvascular endothelial cells.
View Article and Find Full Text PDFLangmuir
January 2025
Ningbo Key Lab of Polymer Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 315211 Ningbo, P. R. China.
Solar-driven desalination technology is currently an important way to obtain freshwater resources. Significantly, porous materials are used as substrate materials of interface solar evaporator, and their specific impact of water transport property and thermal management during evaporation is worth exploring. In this paper, poly(vinyl alcohol) (PVA) sponges were prepared by a chemical foaming method, adjusted the PVA polymerization degree, and formaldehyde-hydroxyl ratio to regulate the pore size, and polypyrrole (PPy) was grown in situ on the surface skeleton of PVA sponge to construct a new interfacial solar evaporator (PPy/PVA) with different pore structures.
View Article and Find Full Text PDFJ Cancer Surviv
January 2025
School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.
Purpose: This meta-analysis aims to estimate the global prevalence of severe, moderate, overall malnutrition and moderating factors of malnutrition in colorectal cancer (CRC) survivors.
Methods: A comprehensive search was conducted in Embase, CINAHL, Medline-OVID, PubMed, Scopus, and Web of Science from inception to February 8, 2024, without language, region, or publication date restrictions. A generalized linear mixed model and random-effects model were used to examine the pooled prevalence, and moderator analyses were implemented to investigate variations in the pooled prevalence.
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