We demonstrate an optical modulator based on a single quantum dot strongly coupled to a photonic crystal cavity. A vertical p-i-n junction is used to tune the quantum dot and thereby modulate the cavity transmission, with a measured instrument-limited response time of 13 ns. A modulator based on a single quantum dot promises operation at high bandwidth and low power.
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http://dx.doi.org/10.1364/OE.17.018651 | DOI Listing |
J Affect Disord
January 2025
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Anhui Province, Hefei 230022, China; Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. Electronic address:
Background: Electroconvulsive therapy (ECT) is an effective treatment for patients with major depressive disorder (MDD), but the underlying neuromodulatory mechanisms remain largely unknown. Functional stability represents a newly developed method based on the dynamic functional connectivity framework. This study aimed to explore ECT-evoked changes in functional stability and their relationship with clinical outcomes.
View Article and Find Full Text PDFDev Cell
January 2025
Biozentrum, University of Basel, 4056 Basel, Switzerland; Allen Discovery Center for Cell Lineage Tracing, Seattle, WA 98195, USA. Electronic address:
The 5' UTRs of mRNAs are critical for translation regulation during development, but their in vivo regulatory features are poorly characterized. Here, we report the regulatory landscape of 5' UTRs during early zebrafish embryogenesis using a massively parallel reporter assay of 18,154 sequences coupled to polysome profiling. We found that the 5' UTR suffices to confer temporal dynamics to translation initiation and identified 86 motifs enriched in 5' UTRs with distinct ribosome recruitment capabilities.
View Article and Find Full Text PDFSmall
January 2025
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
The scarcity of cost-effective and durable iridium-free anode electrocatalysts for the oxygen evolution reaction (OER) poses a significant challenge to the widespread application of the proton exchange membrane water electrolyzer (PEMWE). To address the electrochemical oxidation and dissolution issues of Ru-based electrocatalysts, an electron-donating modification strategy is developed to stabilize WRuO under harsh oxidative conditions. The optimized catalyst with a low Zirconium doping (Zr, 1 wt.
View Article and Find Full Text PDFACS Nano
January 2025
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, United States.
Most traditional optical biosensors operate through molecular recognition, where ligand binding causes conformational changes that lead to optical perturbations in the emitting motif. Optical sensors developed from single-stranded DNA-functionalized single-walled carbon nanotubes (ssDNA-SWCNTs) have started to make useful contributions to biological research. However, the mechanisms underlying their function have remained poorly understood.
View Article and Find Full Text PDFACS Nano
January 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Targeted drug delivery is a promising strategy for treating inflammatory diseases, with recent research focusing on the combination of neutrophils and nanomaterials. In this study, a targeted nanodrug delivery platform (Ac-PGP-tFNA, APT) was developed using tetrahedral framework nucleic acid (tFNA) along with a neutrophil hitchhiking mechanism to achieve precise delivery and anti-inflammatory effects. The tFNA structure, known for its excellent drug-loading capacity and cellular uptake efficiency, was used to carry a therapeutic agent─baicalin.
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