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Autoimmunity to SOX2, clinical phenotype and survival in patients with small-cell lung cancer. | LitMetric

Autoimmunity to SOX2, clinical phenotype and survival in patients with small-cell lung cancer.

Lung Cancer

Department of Neurology, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham NG7 2UH, UK.

Published: December 2010

AI Article Synopsis

  • Autoantibodies to SOXB1 antigens, particularly SOX2, are frequently present in small-cell lung cancer (SCLC) patients, but their role in prognosis remains unclear.
  • A study of 212 SCLC patients found SOX2 antibodies in 70 individuals, showing high specificity but low sensitivity and no distinct clinical phenotype associated with them.
  • Despite being specific markers for SCLC, the presence of SOX2 antibodies does not significantly impact survival outcomes when considering other established prognostic factors.

Article Abstract

Objective: Autoantibodies to SOXB1 antigens are commonly found in patients with small-cell lung cancer (SCLC). It has not been established whether the presence of circulating SOX antibodies is associated with a specific paraneoplastic clinical phenotype, or if a tumour immune response to SOX antigens can affect prognosis in patients with SCLC in relation to other established prognostic factors.

Methods: Using recombinant SOX2 in an ELISA, we analysed sera in a prospective study from 212 unselected SCLC patients, which included 35 patients with neurological paraneoplastic disorders, or other well characterised onconeural antibodies.

Results: Overall, SOX2 antibodies were detected in 70 SCLC patients, with a sensitivity of 33% (95% CI 27-40%) and specificity of 97% (95% CI 94-99%) compared to controls matched for age, gender and smoking history. No single clinical phenotype was seen in relation to the presence of SOX2 antibodies in isolation. Multivariate analysis showed that the presence of SOX2 antibodies in SCLC patients without evidence of neurological paraneoplastic disorders or onconeural antibodies did not have a significant effect on survival when known prognostic factors were accounted for.

Conclusions: SOX2 antibodies are very specific markers for SCLC compared to matched non-tumour controls, but their presence does not seem to alter prognosis in this tumour type.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lungcan.2010.03.002DOI Listing

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