AI Article Synopsis
- The study focused on analyzing microdomains in vesicles made of specific lipids (DOPC, DPPC) and cholesterol using small-angle neutron scattering (SANS) to understand their size and distribution.
- Results indicated that the microdomains are cylindrical in shape, averaging around 15 nm in radius, and are arranged in a fractal-like pattern.
- In multilamellar vesicles, the domains were found to interact across the water layers between the lipid layers, suggesting a coupling effect.
Article Abstract
We examined the structure and distribution of microdomains in ternary multilamellar and unilamellar vesicles representing a canonical model raft mixture consisting of dioleoylphosphatidylcholine (DOPC), dipalmitoylphosphatidylcholine (DPPC), and cholesterol via contrast matched small-angle neutron scattering (SANS). The impetus of the work was to reveal the size and distribution of microdomains consistent with the form factor and intermolecular structure factor S(Q) of the scattering pattern of unilamellar and multilamellar vesicles prepared from this ternary lipid system. The data are consistent with the presence of cylindrically shaped microdomains with an average radius of approximately 15 nm assembled in a fractal-like geometry, and with corresponding modeling studies. In the multilamellar vesicle system, coupling of domains across the interlamellar water layer is observed.
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| http://dx.doi.org/10.1021/jp101167n | DOI Listing |
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