[The inhibition effect of paclitaxel on the proliferation of human pulmonary fibroblasts].

Objective: To observe the influence of paclitaxel on the proliferation of human pulmonary fibroblast (HPF), and therefore to explore the possible effect on granulation tissue formation in-stent restenosis after airway stent.

Methods: The HPFS were divided into 3 groups: 24 h group, 48 h group and 72 h group, and there were 3 different dosage groups in each time group. MTT assay was used for detecting cell proliferation.

Results: The inhibition ratio of 4.5 microg/ml group, 13.5 microg/ml group and 45 microg/ml group were 43.7%, 58.8% and 68.1% after 24 hours; 75.5%, 77.7%, 91.9% after 48 hours; 95.1%, 97.1%, 97.0% after 72 hours.

Conclusions: Paclitaxel inhibited the proliferation of HPF, and the inhibition ratio has partly relation with time and dosage.