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Prostate cancer treatment has undergone vast development over the last few decades, but the most notable changes have included nerve-sparing open radical prostatectomy, laparoscopic radical prostatectomy, including robot-assisted and, more recently, cryotherapy and high-intensity focused ultrasound (HIFU). While radical surgery is the current gold standard, the less invasive therapeutic options of cryotherapy and HIFU are regarded as largely experimental by governing bodies. In the case of cryotherapy, a wealth of experience has been accumulated demonstrating its efficacy. Initially used as a salvage treatment for radiation-failed prostate cancer, cryotherapy has been widely used as a primary treatment for localized and locally advanced prostate cancer. More recently, there has been interest expressed in the concept of focal therapy in prostate cancer. This has been evaluated as a primary treatment for prostate cancer, but little information is available regarding the potential use as a salvage treatment. In this article, we evaluate the potential for focal treatment in the salvage setting.
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http://dx.doi.org/10.1089/end.2009.0451 | DOI Listing |
Expert Rev Anticancer Ther
March 2025
Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Introduction: Prostate cancer represents a significant oncological challenge, with its natural history predominantly driven by androgen receptor (AR) signaling. The pivotal role of this pathway underscores the rationale for targeting AR activity in therapeutic strategies. However, the development of resistance mechanisms has highlighted the need for advanced therapies to address the complexity of the castration-resistant status.
View Article and Find Full Text PDFCardiooncology
March 2025
Department of Medicine and Population Health Research Institute, McMaster University, Hamilton, Canada.
Advances in the diagnosis and management of prostate cancer have significantly changed the disease landscape. While benefiting from better oncological outcomes, patients are now experiencing higher rates of non-cancer comorbidities, including cardiovascular disease. The increasing impact of cardiovascular disease in those with prostate cancer led to the expanding role of cardio-oncology professionals in enhancing the multidisciplinary care of these patients.
View Article and Find Full Text PDFBMC Urol
March 2025
Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: The aim of this study was to assess the feasibility of using magnetic resonance (MR) images to implement a dose painting (DP) approach in prostate high-dose-rate brachytherapy.
Methods: The study included 45 patients with prostate tumors of varying grades, with the tumors (DILs) manually segmented with a 0.5 cm margin on T2W MR Images.
Int J Radiat Oncol Biol Phys
April 2025
Radiation Oncology, Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland; Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address:
Ann Clin Lab Sci
January 2025
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
Objective: Cancer is a common cause of mortality and morbidity, and anemia is a major public health issue globally. This study aimed to determine the morphological types of anemia that occur in newly diagnosed patients with solid malignancies.
Methods: This retrospective study was performed on a total of 345 cancer patients to record the types of anemia found in patients with solid tumors using calculation of indices (MCV, MCH, and MCHC) in blood gathered from patients with various solid cancers.
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