It has been shown that frequency domain optical coherence tomography (FD-OCT) systems achieve higher sensitivities compared to time domain optical coherence tomography (OCT) systems. However, the obscure object structure due to the mirror image generated by the Fourier transform is one of the remaining issues in the FD-OCT. We designed and developed what we believe to be a novel full range FD-OCT system that we refer to as the dual detection full range frequency domain optical coherence tomography (DD-FDOCT) that enables the instantaneous retrieval of quadrature components of the complex interferometric signal. The DD-FDOCT system enables full range imaging without loss of speed, and it may be less sensitive to phase error generated by involuntary movements of the subject compared to the other established full range OCT systems, because it uses two signals with a phase difference of pi/2 obtained simultaneously from two detection arms to remove mirror images at all depths.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1364/OL.35.001058 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Wellbeing and the Lived Experience of Injured Workers Following Finalisation of a Workers' Compensation Claim.
J Occup Rehabil
January 2025
Faculty of Health Sciences, Curtin School of Allied Health, Curtin University, Perth, WA, Australia.
Purpose: Workers' compensation claims can negatively affect the wellbeing of injured workers. For some, these negative effects continue beyond finalisation of the workers' compensation claim. It is unclear what factors influence wellbeing following finalisation of a workers' compensation claim.
View Article and Find Full Text PDFSurgical excision of symptomatic lateral band snapping syndrome in small finger proximal interphalangeal joint.
BMJ Case Rep
January 2025
Orthopedic Surgery, OhioHealth, Columbus, Ohio, USA.
Lateral band snapping syndrome can be a debilitating condition involving the proximal interphalangeal (PIP) joint of the fingers. Although rare, it is thought to occur due to disruption of the finger extensor mechanism allowing inappropriate subluxation of the lateral bands over the PIP joint, leading to mechanical and painful symptoms.Here, we describe a woman in her early 40s with a painful, snapping PIP joint secondary to a work-related injury.
View Article and Find Full Text PDFTargeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery.
Pharmacol Res
January 2025
Department of Cardiology, Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China. Electronic address:
G protein-coupled receptors (GPCRs) represent the largest family of membrane receptors and are highly effective targets for therapeutic drugs. GPCRs couple different downstream effectors, including G proteins (such as Gi/o, Gs, G12, and Gq) and β-arrestins (such as β-arrestin 1 and β-arrestin 2) to mediate diverse cellular and physiological responses. Biased signaling allows for the specific activation of certain pathways from the full range of receptors' signaling capabilities.
View Article and Find Full Text PDFQuality by Design in continuous bioprocessing: Investigating the impact of critical process parameters of multi-column chromatography during steady-state and transient phases.
J Chromatogr A
December 2024
Downstream Processing, Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, Centros #06-01 138668, Singapore. Electronic address:
Given the complexities of continuous bioprocessing, it is critical to thoroughly investigate the process parameters unique to multi-column chromatography (MCC) and their potential impacts. However, existing studies have focused on either loading densities or residence time at steady states only, and their combined impact on critical quality attributes (CQAs) especially during transient phases were less known. In this study, we investigated the impact of critical process parameters during both steady-state and transient phases (start-up, close-down, and intermediate perturbation) through full factorial design.
View Article and Find Full Text PDFImproved ovalbumin accurate quantitative performance in processed foods by full-length isotope-labeled protein.
Food Chem
December 2024
National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, and Beijing Laboratory for Food Quality and Safety, Beijing 100193, China; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China. Electronic address:
Ovalbumin (OVA) is a high-risk allergen with complex tertiary structure in food samples. Here, we developed an accurate UPLC-MS/MS-based assay to improve OVA quantitative performance in processed foods. Full-length isotope-labeled OVA proteins (OVA-I) were synthesized using stable isotope labeling by amino acids in cell culture (SILAC) technique and employed as functional internal standards to ensure similar cleavage sites between internal standards and analytes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!