Aim Of The Study: Cirsium rivulare (Jacq.) All. (Asteraceae) is a herbaceous perennial plant occurring in Central Europe. It has been traditionally used in Polish folk medicine to treat anxiety. In the present study methanolic extracts from flowers and leaves of Cirsium rivulare containing flavonoid compounds linarin, pectolinarin, apigenin, hispidulin, their glycosides and a newly isolated compound isokaemferide 7-O-(6''-methylglucuronide) were studied for anxiolytic and pro-cognitive properties.
Materials And Methods: Male Wistar rats (150-160 g) were used. They were treated orally with standardized methanol extracts of flowers and leaves of Cirsium rivulare and subsequently tested for memory in passive avoidance (PA) and object recognition (OR) tests. Auxiliary tests for motor (open field, OF) and emotional (elevated 'plus' maze, EPM) effects of the above treatments were also employed.
Results: We found that the extract from flowers of Cirsium rivulare, in addition to its anxiolytic effects as measured in the EPM, improves memory of the appetitively (by curiosity, OR) and aversively (by footshook, PA) motivated tasks. This is in contrast to classical anxiolytics as for example benzodiazepines that typically impair memory. The extract from leaves of Cirsium rivulare showed some anxiolytic properties in the EPM, and no effect in both cognitive tests. The examined extracts of Cirsium rivulare did not affect psychomotor exploratory activity of rats tested in the OF.
Conclusions: These results suggest that the flavonoids from Cirsium rivulare possess anxiolytic and pro-cognitive effects, the extract from flowers being more pro-cognitive and that from the leaves more anxiolytic.
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http://dx.doi.org/10.1016/j.jep.2010.03.028 | DOI Listing |
Nat Prod Res
December 2016
a Department of Pharmacognosy , Medical University of Bialystok, Bialystok , Poland.
The mixture of three phytosterols (campesterol, stigmasterol and β-sitosterol), β-sitosterol 3-O-glucoside and syringin were isolated from hexane and methanol extract of Cirsium rivulare roots after chromatographic separation. The main component of the source was syringin which was obtained with the yield 0.08% of the dry source.
View Article and Find Full Text PDFJ Chromatogr Sci
August 2016
Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4A St., Lublin 20-093, Poland.
The dried aerial parts of 12 plants of Cirsium species were extracted with the Soxhlet apparatus using dichloromethane and methanol as solvents. Next, the extracts were separated by TLC methods to obtain the fingerprint chromatograms. The analysis was performed on silica gel or RP-18 layers as stationary phases using the following eluents: ethyl acetate/formic acid/acetic acid/water (12/1.
View Article and Find Full Text PDFTalanta
July 2012
Institute of Chemistry, University of Białystok, ul. Hurtowa 1, 15-399 Białystok, Poland.
The determination of the sum of flavonoid compounds in extracts from inflorescences (expressed as mgL(-1) of apigenin) and leaves (expressed as mgL(-1) of linarin) of Cirsium oleraceum and Cirsium rivulare species by flow injection system with chemiluminescence detection (FI-CL) has been carried out. The method is based on the strong enhancement by polyphenols occurring in both plants of the CL signal generated by the reaction of cerium(IV) with rhodamine 6G in a sulfuric acid medium. Under the optimized conditions, the linear working ranges of 0.
View Article and Find Full Text PDFNat Prod Commun
February 2012
Department of Pharmacognosy, Medical University of Białystok, Mickiewicza 2a Str., 15-089 Białystok, Poland.
The composition of the essential oils of Cirsium palustre and C. rivulare and their antiproliferative activity against breast adenocarcinoma cells (MCF-7 and MDA-MBA-231) were investigated. The essential oils obtained by hydro-distillation from the roots (yield 0.
View Article and Find Full Text PDFNat Prod Res
April 2010
Department of Bromatology, Medical University of Bialystok, 15-089 Białystok, Poland.
In this study, antimicrobial properties and toxicity of extracts from Cirsium spp.: Cirsium arvense, C. oleraceum, C.
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