The 7-alkene-3-quinolinecarbonitrile 20, a potent inhibitor of Src enzymatic and cellular activity with IC(50) values of 2.1 and 58 nM, respectively, had comparable efficacy to bosutinib in a colon tumor xenograft study.
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| http://dx.doi.org/10.1016/j.bmcl.2010.03.025 | DOI Listing |
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